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CG4017 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34296, updated on 4-Apr-2024

Summary

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Official Symbol
CG4017provided by FlyBase
Primary source
FLYBASE:FBgn0032143
Locus tag
Dmel_CG4017
See related
AllianceGenome:FB:FBgn0032143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4017
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic tracheole. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA3 (carboxypeptidase A3); CPB1 (carboxypeptidase B1); and CPB2 (carboxypeptidase B2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
30C8-30C8; 2-36 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9767058..9768727)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9767058..9768727)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene TBP-associated factor 11 Neighboring gene uninitiated Neighboring gene pickpocket 18 Neighboring gene uncharacterized protein Neighboring gene pickpocket 11 Neighboring gene pickpocket 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster as a versatile model organism to study genetic epilepsies: An overview. Fischer FP, et al. Front Mol Neurosci, 2023. PMID 36873106, Free PMC Article
  2. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
  3. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
  4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4017-PA
NP_609309.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9767058..9768727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135465.4 → NP_609309.1  uncharacterized protein Dmel_CG4017 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609309.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGC4, Q9VL87
    Related
    FBpp0079463
    Conserved Domains (2) summary
    cd03860
    Location:119 → 415
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam02244
    Location:30 → 97
    Propep_M14; Carboxypeptidase activation peptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGC4 Q8IGC4
Q9VL87 Q9VL87

Gene LinkOut

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