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ZNF404 zinc finger protein 404 [ Homo sapiens (human) ]

Gene ID: 342908, updated on 13-May-2022

Summary

Official Symbol
ZNF404provided by HGNC
Official Full Name
zinc finger protein 404provided by HGNC
Primary source
HGNC:HGNC:19417
See related
Ensembl:ENSG00000176222 AllianceGenome:HGNC:19417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 3.0), testis (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF404 in Genome Data Viewer
Location:
19q13.31
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43872365..43883964, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46695264..46706862, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44376517..44388116, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LY6/PLAUR domain containing 5 Neighboring gene zinc finger protein 283 Neighboring gene uncharacterized LOC100505715 Neighboring gene ZNF45 antisense RNA 1 Neighboring gene zinc finger protein 45

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
The correlation between reading and mathematics ability at age twelve has a substantial genetic component.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC120455

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033719.3NP_001028891.2  zinc finger protein 404

    See identical proteins and their annotated locations for NP_001028891.2

    Status: VALIDATED

    Source sequence(s)
    AC011508, BC101333, BQ188692
    Consensus CDS
    CCDS59394.1
    UniProtKB/Swiss-Prot
    Q494X3
    Related
    ENSP00000466051.1, ENST00000587539.2
    Conserved Domains (6) summary
    smart00349
    Location:651
    KRAB; krueppel associated box
    COG5048
    Location:106510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:357377
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:482506
    zf-H2C2_2; Zinc-finger double domain
    pfam14353
    Location:413458
    CpXC; CpXC protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43872365..43883964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46695264..46706862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)