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LEUTX leucine twenty homeobox [ Homo sapiens (human) ]

Gene ID: 342900, updated on 3-Mar-2026
Official Symbol
LEUTXprovided by HGNC
Official Full Name
leucine twenty homeoboxprovided by HGNC
Primary source
HGNC:HGNC:31953
See related
Ensembl:ENSG00000213921 MIM:618701; AllianceGenome:HGNC:31953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See LEUTX in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39776453..39786291)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42580718..42590554)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40267093..40276931)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14629 Neighboring gene galectin 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14630 Neighboring gene Charcot-Leyden crystal galectin Neighboring gene uncharacterized LOC124904719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40314468-40315454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40315455-40316439 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1B Neighboring gene microRNA 6719

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation. Jouhilahti EM, et al. Development, 2016 Oct 1. PMID 27578796, Free PMC Article
  2. Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion. Andreiuolo F, et al. Acta Neuropathol Commun, 2024 Mar 18. PMID 38500181, Free PMC Article
  3. Rapid Evolution of the Embryonically Expressed Homeobox Gene LEUTX within Primates. Lewin TD, et al. Genome Biol Evol, 2023 Jun 1. PMID 37232378, Free PMC Article
  4. Classification and nomenclature of all human homeobox genes. Holland PW, et al. BMC Biol, 2007 Oct 26. PMID 17963489, Free PMC Article
  5. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion.
    Title: Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion.
  2. Rapid Evolution of the Embryonically Expressed Homeobox Gene LEUTX within Primates.
    Title: Rapid Evolution of the Embryonically Expressed Homeobox Gene LEUTX within Primates.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
paired-like homeodomain transcription factor LEUTX
Names
PRD-LIKE homeobox transcription factor LEUTX
arginine-fifty homeobox-like pseudogene
paired-like homeobox transcription factor LEUTX
putative leucine-twenty homeobox

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143832.2 → NP_001137304.1  paired-like homeodomain transcription factor LEUTX isoform 2

    See identical proteins and their annotated locations for NP_001137304.1

    Status: VALIDATED

    Source sequence(s)
    AC005393
    UniProtKB/Swiss-Prot
    A8MZ59
    Related
    ENSP00000380053.3, ENST00000396841.4
    Conserved Domains (1) summary
    pfam00046
    Location:1 → 34
    Homeobox; Homeobox domain

  2. NM_001382345.1 → NP_001369274.1  paired-like homeodomain transcription factor LEUTX isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005393
    Consensus CDS
    CCDS92615.1
    UniProtKB/Swiss-Prot
    A0A1W2PQ33, A8MZ59
    Related
    ENSP00000491740.1, ENST00000638280.2
    Conserved Domains (1) summary
    smart00389
    Location:15 → 64
    HOX; Homeodomain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39776453..39786291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646206.1 Reference GRCh38.p14 PATCHES

    Range
    36329..46167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42580718..42590554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_003931.1: Suppressed sequence

    Description
    NR_003931.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MZ59.4 GenPept UniProtKB/Swiss-Prot:A8MZ59

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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