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IFI27 interferon alpha inducible protein 27 [ Homo sapiens (human) ]

Gene ID: 3429, updated on 7-Jun-2020

Summary

Official Symbol
IFI27provided by HGNC
Official Full Name
interferon alpha inducible protein 27provided by HGNC
Primary source
HGNC:HGNC:5397
See related
Ensembl:ENSG00000165949 MIM:600009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P27; ISG12; FAM14D; ISG12A
Expression
Broad expression in stomach (RPKM 224.1), spleen (RPKM 211.7) and 21 other tissues See more
Orthologs

Genomic context

See IFI27 in Genome Data Viewer
Location:
14q32.12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (94110736..94116690)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94577079..94583033)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene DEAD-box helicase 24 Neighboring gene interferon alpha inducible protein 27 like 1 Neighboring gene interferon alpha inducible protein 27 like 2 Neighboring gene uncharacterized LOC105370634

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon, alpha-inducible protein 27 (IFI27) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFI27, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of IFI27 in human monocyte-derived dendritic cells PubMed
vpr HIV-1 Vpr upregulates the gene expression of IFI27 in human monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
lamin binding IDA
Inferred from Direct Assay
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation by host of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein export from nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
type I interferon signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon alpha-inducible protein 27, mitochondrial
Names
2310061N23Rik
ISG12(a)
interferon alpha-induced 11.5 kDa protein
interferon-stimulated gene 12a protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130080.3NP_001123552.1  interferon alpha-inducible protein 27, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001123552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). This variant represents an allele commonly found in the human population and corresponds to the allele present in the GRC reference assembly. Variants 1, 3, 5, 11 and 12 encode the same isoform (1).
    Source sequence(s)
    BN000227
    UniProtKB/Swiss-Prot
    P40305
    UniProtKB/TrEMBL
    A8K0H0
    Conserved Domains (1) summary
    pfam06140
    Location:40116
    Ifi-6-16; Interferon-induced 6-16 family
  2. NM_001288952.2NP_001275881.1  interferon alpha-inducible protein 27, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001275881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' UTR, compared to variant 1. This variant corresponds to the allele present in the GRC reference assembly. Variants 1, 3 and 5, 11 and 12 encode the same isoform (1).
    Source sequence(s)
    AU103232, BC015492, BF971643
    UniProtKB/Swiss-Prot
    P40305
    UniProtKB/TrEMBL
    A8K0H0
    Conserved Domains (1) summary
    pfam06140
    Location:40116
    Ifi-6-16; Interferon-induced 6-16 family
  3. NM_001288954.2NP_001275883.1  interferon alpha-inducible protein 27, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001275883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an additional exon in the 5' UTR and lacks a 9-nt segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal 3 aa segment, as compared to isoform 1. Variants 2, 4, 6, 7 and 10 encode the same isoform.
    Source sequence(s)
    BC015492, BP317624
    Consensus CDS
    CCDS32148.1
    UniProtKB/Swiss-Prot
    P40305
    Related
    ENSP00000477753.1, ENST00000616764.4
    Conserved Domains (1) summary
    pfam06140
    Location:38113
    Ifi-6-16; Interferon-induced 6-16 family
  4. NM_001288956.2NP_001275885.1  interferon alpha-inducible protein 27, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001275885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 1. This variant corresponds to the allele present in the GRC reference assembly. Variants 1, 3 and 5, 11 and 12 encode the same isoform (1).
    Source sequence(s)
    BG483267, BU688913
    UniProtKB/Swiss-Prot
    P40305
    UniProtKB/TrEMBL
    A8K0H0
    Conserved Domains (1) summary
    pfam06140
    Location:40116
    Ifi-6-16; Interferon-induced 6-16 family
  5. NM_001288957.2NP_001275886.1  interferon alpha-inducible protein 27, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001275886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks a 9-nt segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal 3 aa segment, as compared to isoform 1. Variants 2, 4, 6, 7 and 10 encode the same isoform.
    Source sequence(s)
    BC015492
    Consensus CDS
    CCDS32148.1
    UniProtKB/Swiss-Prot
    P40305
    Conserved Domains (1) summary
    pfam06140
    Location:38113
    Ifi-6-16; Interferon-induced 6-16 family
  6. NM_001288958.2NP_001275887.1  interferon alpha-inducible protein 27, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001275887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an internal segment in the 5' UTR and a 9-nt segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal 3 aa segment, as compared to isoform 1. Variants 2, 4, 6, 7 and 10 encode the same isoform.
    Source sequence(s)
    AU103232, AY126456, BM841596, BU688913
    Consensus CDS
    CCDS32148.1
    UniProtKB/Swiss-Prot
    P40305
    UniProtKB/TrEMBL
    Q7Z5R2
    Conserved Domains (1) summary
    pfam06140
    Location:38113
    Ifi-6-16; Interferon-induced 6-16 family
  7. NM_001288959.2NP_001275888.1  interferon alpha-inducible protein 27, mitochondrial isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an internal exon in the 5' region which results in translation initiation at a downstream AUG codon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1. This variant corresponds to the allele present in the GRC reference assembly.
    Source sequence(s)
    BU928223
    UniProtKB/TrEMBL
    A0A087WZF8
    Conserved Domains (1) summary
    pfam06140
    Location:273
    Ifi-6-16; Interferon-induced 6-16 family
  8. NM_001288960.2NP_001275889.1  interferon alpha-inducible protein 27, mitochondrial isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an internal exon in the 5' region and a 9-nt segment in the CDS, and initiates translation at a downstream AUG codon, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BM756566, BU688913
    Related
    ENSP00000482635.1, ENST00000618863.1
    Conserved Domains (1) summary
    pfam06140
    Location:168
    Ifi-6-16; Interferon-induced 6-16 family
  9. NM_001288995.2NP_001275924.1  interferon alpha-inducible protein 27, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001275924.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an internal segment in the 5' UTR and a 9-nt segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal 3 aa segment, as compared to isoform 1. Variants 2, 4, 6, 7 and 10 encode the same isoform.
    Source sequence(s)
    BM841506, BU688913
    Consensus CDS
    CCDS32148.1
    UniProtKB/Swiss-Prot
    P40305
    Conserved Domains (1) summary
    pfam06140
    Location:38113
    Ifi-6-16; Interferon-induced 6-16 family
  10. NM_001366993.1NP_001353922.1  interferon alpha-inducible protein 27, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. This variant represents an allele commonly found in the human population and corresponds to the allele present in the GRC reference assembly. Variants 1, 3, 5, 11 and 12 encode the same isoform (1).
    Source sequence(s)
    AL121838, KF573698
    Related
    ENSP00000483430.1, ENST00000612813.4
    Conserved Domains (1) summary
    pfam06140
    Location:40116
    Ifi-6-16; Interferon-induced 6-16 family
  11. NM_001366994.1NP_001353923.1  interferon alpha-inducible protein 27, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. This variant represents an allele commonly found in the human population and corresponds to the allele present in the GRC reference assembly. Variants 1, 3, 5, 11 and 12 encode the same isoform (1).
    Source sequence(s)
    AL079302, AL121838, KF573698
    Conserved Domains (1) summary
    pfam06140
    Location:40116
    Ifi-6-16; Interferon-induced 6-16 family
  12. NM_005532.5NP_005523.3  interferon alpha-inducible protein 27, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_005523.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate allele that lacks a 9-nt segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal 3 aa segment, as compared to isoform 1. This variant represents a second allele commonly found in the human population.
    Source sequence(s)
    BM841596, BU688913
    Consensus CDS
    CCDS32148.1
    UniProtKB/Swiss-Prot
    P40305
    Related
    ENSP00000483498.1, ENST00000621160.4
    Conserved Domains (1) summary
    pfam06140
    Location:38113
    Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    94110736..94116690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1225298..1231252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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