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VSTM2B V-set and transmembrane domain containing 2B [ Homo sapiens (human) ]

Gene ID: 342865, updated on 4-Oct-2020

Summary

Official Symbol
VSTM2Bprovided by HGNC
Official Full Name
V-set and transmembrane domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:33595
See related
Ensembl:ENSG00000187135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward brain (RPKM 9.7) See more
Orthologs

Genomic context

See VSTM2B in Genome Data Viewer
Location:
19q12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (29525418..29564555)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30017491..30055458)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 340, pseudogene Neighboring gene VSTM2B divergent transcript Neighboring gene Sharpr-MPRA regulatory region 9443 Neighboring gene uncharacterized LOC105372353 Neighboring gene POP4 homolog, ribonuclease P/MRP subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetic variants associated with disordered eating.
GeneReviews: Not available
Genome-wide meta-analysis for severe diabetic retinopathy.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
V-set and transmembrane domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146339.2NP_001139811.1  V-set and transmembrane domain-containing protein 2B isoform 1 precursor

    See identical proteins and their annotated locations for NP_001139811.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC011474
    Consensus CDS
    CCDS46034.1
    UniProtKB/Swiss-Prot
    A6NLU5
    Related
    ENSP00000335038.6, ENST00000335523.7
    Conserved Domains (2) summary
    smart00410
    Location:34139
    IG_like; Immunoglobulin like
    cl11960
    Location:32138
    Ig; Immunoglobulin domain
  2. NM_001384640.1NP_001371569.1  V-set and transmembrane domain-containing protein 2B isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011474
  3. NM_001384641.1NP_001371570.1  V-set and transmembrane domain-containing protein 2B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC011474
  4. NM_001384642.1NP_001371571.1  V-set and transmembrane domain-containing protein 2B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC011474
  5. NM_001384643.1NP_001371572.1  V-set and transmembrane domain-containing protein 2B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC011474

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    29525418..29564555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526902.2XP_011525204.1  V-set and transmembrane domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011525204.1

    UniProtKB/Swiss-Prot
    A6NLU5
    Conserved Domains (2) summary
    smart00410
    Location:34139
    IG_like; Immunoglobulin like
    cl11960
    Location:32138
    Ig; Immunoglobulin domain
  2. XM_011526903.2XP_011525205.1  V-set and transmembrane domain-containing protein 2B isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:34129
    IG_like; Immunoglobulin like
    pfam07686
    Location:32128
    V-set; Immunoglobulin V-set domain
  3. XM_011526905.2XP_011525207.1  V-set and transmembrane domain-containing protein 2B isoform X4

    Conserved Domains (1) summary
    smart00410
    Location:3775
    IG_like; Immunoglobulin like
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