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Mtpalpha Mitochondrial trifunctional protein alpha subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34276, updated on 7-Sep-2023

Summary

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Official Symbol
Mtpalphaprovided by FlyBase
Official Full Name
Mitochondrial trifunctional protein alpha subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0028479
Locus tag
Dmel_CG4389
See related
AllianceGenome:FB:FBgn0028479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH12558; CG 4389; CG4389; Dmel\CG4389; Hadha; HADHA; LBP; Mtp alpha
Summary
Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Involved in determination of adult lifespan; fatty acid beta-oxidation; and response to starvation. Located in peroxisome. Is expressed in adult head; adult heart; organism; and spermatozoon. Used to study fatty liver disease and lipid metabolism disorder. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Mtpalpha in Genome Data Viewer
Location:
30B12-30B12; 2-35 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9573563..9576769, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9573563..9576769, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene junctophilin Neighboring gene long non-coding RNA:CR44149 Neighboring gene brickwall Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43621 Neighboring gene glial cells missing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impaired fatty acid oxidation in a Drosophila model of mitochondrial trifunctional protein (MTP) deficiency. Kishita Y, et al. Biochem Biophys Res Commun, 2012 Mar 9. PMID 22342726
  2. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Katewa SD, et al. Cell Metab, 2012 Jul 3. PMID 22768842, Free PMC Article
  3. Comparison of cardiolipins from Drosophila strains with mutations in putative remodeling enzymes. Schlame M, et al. Chem Phys Lipids, 2012 Jul. PMID 22465155
  4. Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. Llavero Hurtado M, et al. Sci Rep, 2017 Sep 29. PMID 28963550, Free PMC Article
  5. Pre-adult exposure to three heavy metals leads to changes in the head transcriptome of adult flies. Felmlee KR, et al. MicroPubl Biol, 2022. PMID 35856016, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial trifunctional protein alpha subunit
Names
CG4389-PA
CG4389-PB
Mtpalpha-PA
Mtpalpha-PB
NP_609299.1
NP_723470.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9573563..9576769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164860.2 → NP_723470.1  mitochondrial trifunctional protein alpha subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723470.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPE8
    Related
    FBpp0079453, FBtr0079857
    Conserved Domains (4) summary
    cd06558
    Location:13 → 196
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    TIGR02441
    Location:1 → 736
    fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
    pfam00725
    Location:517 → 612
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:336 → 514
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

  2. NM_135455.3 → NP_609299.1  mitochondrial trifunctional protein alpha subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609299.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V397
    Related
    FBpp0079454, FBtr0079858
    Conserved Domains (4) summary
    cd06558
    Location:52 → 235
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    TIGR02441
    Location:38 → 775
    fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
    pfam00725
    Location:556 → 651
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:375 → 553
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IPE8 Q8IPE8
Q9V397 Q9V397

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