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CD300E CD300e molecule [ Homo sapiens (human) ]

Gene ID: 342510, updated on 25-Nov-2025
Official Symbol
CD300Eprovided by HGNC
Official Full Name
CD300e moleculeprovided by HGNC
Primary source
HGNC:HGNC:28874
See related
Ensembl:ENSG00000186407 MIM:609801; AllianceGenome:HGNC:28874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM2; CLM-2; IREM2; PIgR2; IREM-2; PIgR-2; CD300LE; CMRF35-A5
Summary
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
Expression
Biased expression in appendix (RPKM 19.2), bone marrow (RPKM 15.3) and 4 other tissues See more
Orthologs
all
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See CD300E in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74609885..74623738, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75500469..75514322, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72606024..72619877, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72564995-72565725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72565726-72566455 Neighboring gene CD300H molecule (gene/pseudogene) Neighboring gene CD300LD antisense RNA 1 Neighboring gene CD300 molecule like family member d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12713 Neighboring gene uncharacterized LOC101928343 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72627822-72628322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72628323-72628823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12714 Neighboring gene RAB37 antisense RNA 1 Neighboring gene RAB37, member RAS oncogene family Neighboring gene CD300 molecule like family member f

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells. Brckalo T, et al. Eur J Immunol, 2010 Mar. PMID 20039296
  2. The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation. Coletta S, et al. Sci Rep, 2020 Oct 5. PMID 33020563, Free PMC Article
  3. Molecular characterization of a novel immune receptor restricted to the monocytic lineage. Aguilar H, et al. J Immunol, 2004 Dec 1. PMID 15557162
  4. IREM-1 is a novel inhibitory receptor expressed by myeloid cells. Alvarez-Errico D, et al. Eur J Immunol, 2004 Dec. PMID 15549731
  5. Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways. Martínez-Barriocanal A, et al. J Immunol, 2006 Sep 1. PMID 16920917

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation.
    Title: The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation.
  2. CD300E expression is significantly upregulated in human masticatory mucosa during wound healing
    Title: Human gingiva transcriptome during wound healing.
  3. CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.
    Title: CD300 molecule regulation of human dendritic cell functions.
  4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.
  5. IREM-2 is a novel activating immunoglobulin-like receptor expressed on mature hemopoietic cells of the monocytic and myeloid dendritic cell lineages.
    Title: Molecular characterization of a novel immune receptor restricted to the monocytic lineage.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cocaine binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
Preferred Names
CMRF35-like molecule 2
Names
CD300 antigen-like family member E
CD300e antigen
immune receptor expressed on myeloid cells 2
poly-Ig receptor 2
polymeric immunoglobulin receptor 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181449.3 → NP_852114.2  CMRF35-like molecule 2 precursor

    See identical proteins and their annotated locations for NP_852114.2

    Status: VALIDATED

    Source sequence(s)
    AC064805, AK303545, BC100890
    Consensus CDS
    CCDS11702.1
    UniProtKB/Swiss-Prot
    B4DNS1, Q496F6, Q7Z7I3
    UniProtKB/TrEMBL
    C9JDD2
    Related
    ENSP00000376395.2, ENST00000392619.2
    Conserved Domains (2) summary
    cd05716
    Location:24 → 104
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:21 → 104
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74609885..74623738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75500469..75514322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q496F6.2 GenPept UniProtKB/Swiss-Prot:Q496F6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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