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CD300E CD300e molecule [ Homo sapiens (human) ]

Gene ID: 342510, updated on 15-Jun-2019


Official Symbol
CD300Eprovided by HGNC
Official Full Name
CD300e moleculeprovided by HGNC
Primary source
See related
Ensembl:ENSG00000186407 MIM:609801
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM2; CLM-2; IREM2; PIgR2; IREM-2; PIgR-2; CD300LE; CMRF35-A5
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
Biased expression in appendix (RPKM 19.2), bone marrow (RPKM 15.3) and 4 other tissues See more

Genomic context

See CD300E in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (74609883..74623958, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72606022..72619897, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CD300H molecule (gene/pseudogene) Neighboring gene CD300 molecule like family member d Neighboring gene chromosome 17 open reading frame 77 Neighboring gene uncharacterized LOC101928343 Neighboring gene uncharacterized LOC107985069 Neighboring gene uncharacterized LOC105371894 Neighboring gene RAB37, member RAS oncogene family

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Process Evidence Code Pubs
innate immune response TAS
Traceable Author Statement
more info
regulation of immune response TAS
Traceable Author Statement
more info
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
CMRF35-like molecule 2
CD300 antigen-like family member E
CD300e antigen
immune receptor expressed on myeloid cells 2
poly-Ig receptor 2
polymeric immunoglobulin receptor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181449.3NP_852114.2  CMRF35-like molecule 2 precursor

    See identical proteins and their annotated locations for NP_852114.2

    Status: VALIDATED

    Source sequence(s)
    AC064805, AK303545, BC100890
    Consensus CDS
    ENSP00000376395.2, ENST00000392619.2
    Conserved Domains (2) summary
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    74609885..74623958 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024575.1XP_016880064.1  CMRF35-like molecule 2 isoform X1

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