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CD300E CD300e molecule [ Homo sapiens (human) ]

Gene ID: 342510, updated on 26-Nov-2021

Summary

Official Symbol
CD300Eprovided by HGNC
Official Full Name
CD300e moleculeprovided by HGNC
Primary source
HGNC:HGNC:28874
See related
Ensembl:ENSG00000186407 MIM:609801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM2; CLM-2; IREM2; PIgR2; IREM-2; PIgR-2; CD300LE; CMRF35-A5
Summary
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
Expression
Biased expression in appendix (RPKM 19.2), bone marrow (RPKM 15.3) and 4 other tissues See more
Orthologs
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Genomic context

See CD300E in Genome Data Viewer
Location:
17q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74609885..74623958, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72606024..72619877, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CD300H molecule (gene/pseudogene) Neighboring gene CD300LD antisense RNA 1 Neighboring gene CD300 molecule like family member d Neighboring gene uncharacterized LOC101928343 Neighboring gene uncharacterized LOC105371894 Neighboring gene RAB37, member RAS oncogene family Neighboring gene CD300 molecule like family member f

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CMRF35-like molecule 2
Names
CD300 antigen-like family member E
CD300e antigen
immune receptor expressed on myeloid cells 2
poly-Ig receptor 2
polymeric immunoglobulin receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181449.3NP_852114.2  CMRF35-like molecule 2 precursor

    See identical proteins and their annotated locations for NP_852114.2

    Status: VALIDATED

    Source sequence(s)
    AC064805, AK303545, BC100890
    Consensus CDS
    CCDS11702.1
    UniProtKB/Swiss-Prot
    Q496F6
    UniProtKB/TrEMBL
    B4E0V9
    Related
    ENSP00000376395.2, ENST00000392619.2
    Conserved Domains (2) summary
    cd05716
    Location:24104
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:21104
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74609885..74623958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024575.1XP_016880064.1  CMRF35-like molecule 2 isoform X1

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