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TMC3 transmembrane channel like 3 [ Homo sapiens (human) ]

Gene ID: 342125, updated on 30-Jun-2019

Summary

Official Symbol
TMC3provided by HGNC
Official Full Name
transmembrane channel like 3provided by HGNC
Primary source
HGNC:HGNC:22995
See related
Ensembl:ENSG00000188869 MIM:617196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TMC3 in Genome Data Viewer
Location:
15q25.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (81331088..81374213, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (81624760..81666418, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 161 Neighboring gene acidic nuclear phosphoprotein 32 family member B pseudogene 3 Neighboring gene interleukin 16 Neighboring gene StAR related lipid transfer domain containing 5 Neighboring gene TMC3 antisense RNA 1 Neighboring gene uncharacterized LOC102723985 Neighboring gene uncharacterized LOC105370921

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mechanosensitive ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane channel-like protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054935.1 RefSeqGene

    Range
    4922..47973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080532.3NP_001074001.1  transmembrane channel-like protein 3

    See identical proteins and their annotated locations for NP_001074001.1

    Status: VALIDATED

    Source sequence(s)
    AC103858, AY236490, AY263163, BC157874
    Consensus CDS
    CCDS45324.1
    UniProtKB/Swiss-Prot
    Q7Z5M5
    Related
    ENSP00000352413.5, ENST00000359440.6
    Conserved Domains (1) summary
    pfam07810
    Location:504610
    TMC; TMC domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    81331088..81374213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181841.1: Suppressed sequence

    Description
    NM_181841.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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