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COX8C cytochrome c oxidase subunit 8C [ Homo sapiens (human) ]

Gene ID: 341947, updated on 22-Sep-2022

Summary

Official Symbol
COX8Cprovided by HGNC
Official Full Name
cytochrome c oxidase subunit 8Cprovided by HGNC
Primary source
HGNC:HGNC:24382
See related
Ensembl:ENSG00000187581 MIM:616855; AllianceGenome:HGNC:24382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COX8-3
Summary
Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 13.0) See more
Orthologs
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Genomic context

See COX8C in Genome Data Viewer
Location:
14q32.12
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (93347182..93348356)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (87579055..87580228)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93813528..93814702)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18a pseudogene 1 Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 Neighboring gene ribosomal protein L36a pseudogene 4 Neighboring gene BTB domain containing 7 Neighboring gene unc-79 homolog, NALCN channel complex subunit Neighboring gene RNA, U6 small nuclear 1258, pseudogene Neighboring gene uncharacterized LOC124903367

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • MGC119774, MGC119775

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of mitochondrial respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit 8C, mitochondrial
Names
COX VIII-3
cytochrome c oxidase polypeptide 8
cytochrome c oxidase polypeptide VIII
cytochrome c oxidase subunit 8-3
cytochrome c oxidase subunit VIII
cytochrome c oxidase subunit VIIIC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182971.3NP_892016.1  cytochrome c oxidase subunit 8C, mitochondrial

    See identical proteins and their annotated locations for NP_892016.1

    Status: VALIDATED

    Source sequence(s)
    AL122023, AY161004, BC101125
    Consensus CDS
    CCDS9910.1
    UniProtKB/Swiss-Prot
    Q495K7, Q7Z4L0
    Related
    ENSP00000340568.2, ENST00000342144.3
    Conserved Domains (1) summary
    cd00930
    Location:2972
    Cyt_c_Oxidase_VIII; Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    93347182..93348356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    461744..462918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    87579055..87580228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)