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IDH3A isocitrate dehydrogenase 3 (NAD(+)) alpha [ Homo sapiens (human) ]

Gene ID: 3419, updated on 5-Aug-2018

Summary

Official Symbol
IDH3Aprovided by HGNC
Official Full Name
isocitrate dehydrogenase 3 (NAD(+)) alphaprovided by HGNC
Primary source
HGNC:HGNC:5384
See related
Ensembl:ENSG00000166411 MIM:601149; Vega:OTTHUMG00000143732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 59.2), adrenal (RPKM 37.1) and 25 other tissues See more
Orthologs

Genomic context

See IDH3A in Genome Data Viewer
Location:
15q25.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (78149362..78170542)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78441698..78462884)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene uncharacterized LOC105370911 Neighboring gene uncharacterized LOC105370910 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify isocitrate dehydrogenase 3 (NAD+) alpha subunit (IDH3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify isocitrate dehydrogenase 3 (NAD+) alpha subunit (IDH3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify isocitrate dehydrogenase 3 (NAD+) alpha subunit (IDH3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with isocitrate dehydrogenase 3 (NAD+) alpha (IDH3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify isocitrate dehydrogenase 3 (NAD+) alpha subunit (IDH3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
isocitrate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Names
H-IDH alpha
NAD(+)-specific ICDH subunit alpha
NAD(H)-specific isocitrate dehydrogenase alpha subunit
NAD+-specific ICDH
isocitrate dehydrogenase (NAD+) alpha chain
isocitrate dehydrogenase 3 (NAD+) alpha
isocitric dehydrogenase subunit alpha
NP_005521.1
XP_005254393.1
XP_024305679.1
XP_024305680.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005530.2NP_005521.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor

    See identical proteins and their annotated locations for NP_005521.1

    Status: REVIEWED

    Source sequence(s)
    BC036227
    Consensus CDS
    CCDS10297.1
    UniProtKB/Swiss-Prot
    P50213
    Related
    ENSP00000299518.2, OTTHUMP00000184906, ENST00000299518.6, OTTHUMT00000289799
    Conserved Domains (1) summary
    TIGR00175
    Location:29362
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    78149362..78170542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449911.1XP_024305679.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X1

  2. XM_024449912.1XP_024305680.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00445
    Location:1253
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase
  3. XM_005254336.3XP_005254393.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_005254393.1

    UniProtKB/TrEMBL
    B7Z9J8
    Conserved Domains (1) summary
    cl00445
    Location:1253
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase
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