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OR6S1 olfactory receptor family 6 subfamily S member 1 [ Homo sapiens (human) ]

Gene ID: 341799, updated on 5-Mar-2024

Summary

Official Symbol
OR6S1provided by HGNC
Official Full Name
olfactory receptor family 6 subfamily S member 1provided by HGNC
Primary source
HGNC:HGNC:15363
See related
Ensembl:ENSG00000181803 AllianceGenome:HGNC:15363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR6S1Q; OR14-37
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR6S1 in Genome Data Viewer
Location:
14q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20640696..20641691, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14837806..14838801, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21108855..21109850, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr (anticodon TGT) 4-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8083 Neighboring gene Sharpr-MPRA regulatory region 11977 Neighboring gene tRNA-Pro (anticodon TGG) 1-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:21110787-21111472 Neighboring gene uncharacterized LOC124903281 Neighboring gene tRNA-Tyr (anticodon GTA) 5-3 Neighboring gene tRNA-Tyr (anticodon GTA) 4-1

Genomic regions, transcripts, and products

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of olfactory receptor, family 6, subfamily S, member 1 (OR6S1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
olfactory receptor 6S1
Names
olfactory receptor OR14-37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001968.1NP_001001968.1  olfactory receptor 6S1

    See identical proteins and their annotated locations for NP_001001968.1

    Status: PROVISIONAL

    Source sequence(s)
    BK004263
    Consensus CDS
    CCDS32038.1
    UniProtKB/Swiss-Prot
    Q6IFJ9, Q8NH40
    UniProtKB/TrEMBL
    A0A126GWN5
    Related
    ENSP00000313110.3, ENST00000320704.3
    Conserved Domains (2) summary
    pfam00001
    Location:43293
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:33308
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    20640696..20641691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    14837806..14838801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)