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grk gurken [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34171, updated on 5-Jan-2023

Summary

Official Symbol
grkprovided by FlyBase
Official Full Name
gurkenprovided by FlyBase
Primary source
FLYBASE:FBgn0001137
Locus tag
Dmel_CG17610
See related
AllianceGenome:FB:FBgn0001137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17610; CT32746; Dmel\CG17610; Grk; GRK; Gurken; s-Grk
Summary
Enables epidermal growth factor receptor binding activity and receptor ligand activity. Involved in several processes, including oogenesis; positive regulation of border follicle cell migration; and regionalization. Located in extracellular space and plasma membrane. Is expressed in germarium region 2; germarium region 2b; nurse cell; oocyte; and ovary. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See grk in Genome Data Viewer
Location:
29C4-29C4; 2-32 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8431086..8433598, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8431086..8433598, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene A kinase anchor protein 200 Neighboring gene D12 Neighboring gene Chromatin accessibility complex 14kD protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, follicular epithelium TAS
Traceable Author Statement
more info
PubMed 
involved_in anterior/posterior pattern specification TAS
Traceable Author Statement
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chorion-containing eggshell pattern formation HMP PubMed 
involved_in determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal/ventral axis specification, ovarian follicular epithelium TAS
Traceable Author Statement
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte anterior/posterior axis specification TAS
Traceable Author Statement
more info
PubMed 
involved_in oocyte dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte dorsal/ventral axis specification TAS
Traceable Author Statement
more info
PubMed 
involved_in oocyte microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of border follicle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
gurken
Names
CG17610-PA
Gurken/epidermal growth factor
grk-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8431086..8433598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057220.3NP_476568.2  gurken [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476568.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42287, Q9VLL2
    Related
    FBpp0079313, FBtr0079708