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CG13398 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34169, updated on 4-Apr-2024

Summary

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Official Symbol
CG13398provided by FlyBase
Primary source
FLYBASE:FBgn0032042
Locus tag
Dmel_CG13398
See related
AllianceGenome:FB:FBgn0032042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG13398
Summary
Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in embryonic/larval midgut; organism; wing hinge primordium; and wing pouch. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2) and FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
29C3-29C3; 2-32 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8412144..8415256, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8412144..8415256, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44991 Neighboring gene embargoed Neighboring gene N-acetyl-alpha-glucosaminidase Neighboring gene A kinase anchor protein 200 Neighboring gene gurken Neighboring gene D12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Akap200 suppresses the effects of Dv-cbl expression in the Drosophila eye. Sannang RT, et al. Mol Cell Biochem, 2012 Oct. PMID 22773306
  2. A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling. Trivedi D, et al. Elife, 2020 Dec 15. PMID 33320085, Free PMC Article
  3. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Molnar C, et al. Genetics, 2012 Oct. PMID 22798488, Free PMC Article
  4. Phosphoinositide signalling in Drosophila. Balakrishnan SS, et al. Biochim Biophys Acta, 2015 Jun. PMID 25449646
  5. A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. Molnar C, et al. Genetics, 2006 Nov. PMID 16980395, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG13398-PA
CG13398-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8412144..8415256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273323.1 → NP_001260252.1  uncharacterized protein Dmel_CG13398, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260252.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MT60, Q9VLL4
    Conserved Domains (1) summary
    cd01202
    Location:15 → 109
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

  2. NM_135383.2 → NP_609227.1  uncharacterized protein Dmel_CG13398, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609227.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MT60, Q9VLL4
    Related
    FBpp0079315
    Conserved Domains (1) summary
    cd01202
    Location:15 → 109
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MT60 Q8MT60
Q9VLL4 Q9VLL4

Gene LinkOut

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