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NEK5 NIMA related kinase 5 [ Homo sapiens (human) ]

Gene ID: 341676, updated on 6-Nov-2022

Summary

Official Symbol
NEK5provided by HGNC
Official Full Name
NIMA related kinase 5provided by HGNC
Primary source
HGNC:HGNC:7748
See related
Ensembl:ENSG00000197168 MIM:616731; AllianceGenome:HGNC:7748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within positive regulation of cysteine-type endopeptidase activity and positive regulation of striated muscle cell differentiation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 3.0), lung (RPKM 0.4) and 1 other tissue See more
Orthologs
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Genomic context

See NEK5 in Genome Data Viewer
Location:
13q14.3
Exon count:
30
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52033611..52129073, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51248427..51343906, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52607747..52703209, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase copper transporting beta Neighboring gene fatty acid binding protein 5 pseudogene 2 Neighboring gene ALG11 alpha-1,2-mannosyltransferase Neighboring gene UTP14C small subunit processome component Neighboring gene Sharpr-MPRA regulatory region 10224 Neighboring gene Sharpr-MPRA regulatory region 2352 Neighboring gene uncharacterized LOC101929657 Neighboring gene uncharacterized LOC124903176 Neighboring gene NIMA related kinase 3 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 5 Neighboring gene thrombospondin type 1 domain containing 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC75495

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek5
Names
NIMA (never in mitosis gene a)-related kinase 5
nimA-related protein kinase 5
NP_001352481.1
NP_954983.1
XP_006719871.2
XP_011533368.1
XP_011533370.1
XP_016876045.1
XP_047286243.1
XP_047286244.1
XP_047286245.1
XP_047286246.1
XP_047286247.1
XP_047286248.1
XP_047286249.1
XP_047286250.1
XP_047286251.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365552.1NP_001352481.1  serine/threonine-protein kinase Nek5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL139082
    Consensus CDS
    CCDS91811.1
    UniProtKB/TrEMBL
    A0A8I5KQI9
    Related
    ENSP00000509632.1, ENST00000684899.1
    Conserved Domains (1) summary
    cd08225
    Location:3259
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
  2. NM_199289.3NP_954983.1  serine/threonine-protein kinase Nek5 isoform 1

    See identical proteins and their annotated locations for NP_954983.1

    Status: VALIDATED

    Source sequence(s)
    AL139082, BC063885, HY018243
    Consensus CDS
    CCDS31979.1
    UniProtKB/Swiss-Prot
    Q5TAP5, Q6P3R8
    Related
    ENSP00000347767.4, ENST00000355568.8
    Conserved Domains (2) summary
    cd08225
    Location:3259
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:4259
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    52033611..52129073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430292.1XP_047286248.1  serine/threonine-protein kinase Nek5 isoform X6

    UniProtKB/TrEMBL
    A0A8I5KQI9
  2. XM_047430293.1XP_047286249.1  serine/threonine-protein kinase Nek5 isoform X7

  3. XM_047430291.1XP_047286247.1  serine/threonine-protein kinase Nek5 isoform X5

  4. XM_047430290.1XP_047286246.1  serine/threonine-protein kinase Nek5 isoform X4

  5. XM_047430288.1XP_047286244.1  serine/threonine-protein kinase Nek5 isoform X2

  6. XM_047430287.1XP_047286243.1  serine/threonine-protein kinase Nek5 isoform X1

  7. XM_047430289.1XP_047286245.1  serine/threonine-protein kinase Nek5 isoform X3

  8. XM_047430294.1XP_047286250.1  serine/threonine-protein kinase Nek5 isoform X8

  9. XM_047430295.1XP_047286251.1  serine/threonine-protein kinase Nek5 isoform X11

  10. XM_011535066.3XP_011533368.1  serine/threonine-protein kinase Nek5 isoform X10

    Conserved Domains (2) summary
    cd08225
    Location:75331
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:76331
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  11. XM_017020556.2XP_016876045.1  serine/threonine-protein kinase Nek5 isoform X9

  12. XM_006719808.5XP_006719871.2  serine/threonine-protein kinase Nek5 isoform X12

    Conserved Domains (2) summary
    cd08225
    Location:75331
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:76331
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  13. XM_011535068.3XP_011533370.1  serine/threonine-protein kinase Nek5 isoform X13

    Conserved Domains (2) summary
    cd08225
    Location:75331
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:76331
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RNA

  1. XR_941575.3 RNA Sequence

  2. XR_941574.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    51248427..51343906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)