U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H1-7 H1.7 linker histone [ Homo sapiens (human) ]

Gene ID: 341567, updated on 9-Dec-2024

Summary

Official Symbol
H1-7provided by HGNC
Official Full Name
H1.7 linker histoneprovided by HGNC
Primary source
HGNC:HGNC:24893
See related
Ensembl:ENSG00000187166 MIM:618565; AllianceGenome:HGNC:24893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1.7; H1T2; H1FNT
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H1-7 in Genome Data Viewer
Location:
12q13.11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48328980..48330279)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48290314..48291613)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48722763..48724062)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102725258 Neighboring gene olfactory receptor family 10 subfamily AD member 1 Neighboring gene MPRA-validated peak1716 silencer Neighboring gene uncharacterized LOC105369753 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48723521-48724020 Neighboring gene zinc finger protein 641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48744721-48745457 Neighboring gene olfactory receptor family 5 subfamily BK member 1 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sperm DNA condensation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in spermatid nucleus elongation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
testis-specific H1 histone
Names
H1 histone family member N, testis specific
HANP1
haploid germ cell-specific nuclear protein 1
histone H1.7
histone H1t2
testis secretory sperm-binding protein Li 223n

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181788.1NP_861453.1  testis-specific H1 histone

    See identical proteins and their annotated locations for NP_861453.1

    Status: REVIEWED

    Source sequence(s)
    AY302593
    Consensus CDS
    CCDS8762.1
    UniProtKB/Swiss-Prot
    Q147U8, Q5GKZ5, Q75WM6, Q7Z694
    UniProtKB/TrEMBL
    A0A140VK96
    Related
    ENSP00000334805.1, ENST00000335017.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48328980..48330279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48290314..48291613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)