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ACSM4 acyl-CoA synthetase medium chain family member 4 [ Homo sapiens (human) ]

Gene ID: 341392, updated on 13-May-2022

Summary

Official Symbol
ACSM4provided by HGNC
Official Full Name
acyl-CoA synthetase medium chain family member 4provided by HGNC
Primary source
HGNC:HGNC:32016
See related
Ensembl:ENSG00000215009 MIM:614360; AllianceGenome:HGNC:32016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable decanoate-CoA ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be active in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 1.5), testis (RPKM 0.7) and 14 other tissues See more
Orthologs
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Genomic context

See ACSM4 in Genome Data Viewer
Location:
12p13.31
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7304072..7328719)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7317413..7342059)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7456668..7481315)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 5 Neighboring gene acyl-CoA synthetase medium chain family member 6 pseudogene Neighboring gene CD163 molecule like 1 Neighboring gene uncharacterized LOC101927882 Neighboring gene M-phase phosphoprotein 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables butyrate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables decanoate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
acyl-coenzyme A synthetase ACSM4, mitochondrial
NP_001073923.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080454.2NP_001073923.1  acyl-coenzyme A synthetase ACSM4, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001073923.1

    Status: VALIDATED

    Source sequence(s)
    AC131205
    Consensus CDS
    CCDS44825.1
    UniProtKB/Swiss-Prot
    P0C7M7
    Related
    ENSP00000382349.4, ENST00000399422.5
    Conserved Domains (2) summary
    cd05928
    Location:48577
    MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)
    COG0365
    Location:49580
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    7304072..7328719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    7317413..7342059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)