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OVCH1 ovochymase 1 [ Homo sapiens (human) ]

Gene ID: 341350, updated on 25-Jan-2022

Summary

Official Symbol
OVCH1provided by HGNC
Official Full Name
ovochymase 1provided by HGNC
Primary source
HGNC:HGNC:23080
See related
Ensembl:ENSG00000187950 AllianceGenome:HGNC:23080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OVCH
Summary
Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OVCH1 in Genome Data Viewer
Location:
12p11.22
Exon count:
30
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (29420822..29499693, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (29590957..29652626, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene fatty acyl-CoA reductase 2 Neighboring gene uncharacterized LOC100506606 Neighboring gene ERGIC and golgi 2 Neighboring gene OVCH1 antisense RNA 1 Neighboring gene uncharacterized LOC105369714 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 1 Neighboring gene ribosomal protein L21 pseudogene 99

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353179.2NP_001340108.1  ovochymase-1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC012151
    Related
    ENSP00000326708.5, ENST00000318184.9
    Conserved Domains (3) summary
    cd00041
    Location:454565
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:610845
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl00049
    Location:10221088
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    29420822..29499693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448968.1XP_024304736.1  ovochymase-1 isoform X1

    Conserved Domains (2) summary
    cd00041
    Location:454565
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:610845
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_011520638.2XP_011518940.1  ovochymase-1 isoform X2

    Conserved Domains (3) summary
    smart00020
    Location:609842
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:454565
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:610845
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_017019256.1XP_016874745.1  ovochymase-1 isoform X3

  4. XM_011520641.2XP_011518943.1  ovochymase-1 isoform X4

    See identical proteins and their annotated locations for XP_011518943.1

    Conserved Domains (3) summary
    smart00020
    Location:46291
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:454565
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:58294
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_011520640.2XP_011518942.1  ovochymase-1 isoform X4

    See identical proteins and their annotated locations for XP_011518942.1

    Conserved Domains (3) summary
    smart00020
    Location:46291
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:454565
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:58294
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  6. XM_011520642.2XP_011518944.1  ovochymase-1 isoform X5

    Conserved Domains (4) summary
    smart00020
    Location:46291
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:454565
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:58294
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:610680
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  7. XM_024448969.1XP_024304737.1  ovochymase-1 isoform X6

    Conserved Domains (2) summary
    cd00041
    Location:454565
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:58294
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. XR_001748684.1 RNA Sequence

  2. XR_931286.2 RNA Sequence

  3. XR_931285.2 RNA Sequence

  4. XR_002957323.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183378.2: Suppressed sequence

    Description
    NM_183378.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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