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OVCH2 ovochymase 2 [ Homo sapiens (human) ]

Gene ID: 341277, updated on 5-Jan-2022

Summary

Official Symbol
OVCH2provided by HGNC
Official Full Name
ovochymase 2provided by HGNC
Primary source
HGNC:HGNC:29970
See related
Ensembl:ENSG00000183378 MIM:618962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OVTN
Summary
Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in skin (RPKM 2.1), kidney (RPKM 1.0) and 5 other tissues See more
Orthologs
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Genomic context

See OVCH2 in Genome Data Viewer
Location:
11p15.4
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (7678623..7706894, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (7710668..7728024, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PPFIA binding protein 2 Neighboring gene uncharacterized LOC105376535 Neighboring gene cytochrome b5 reductase 2 Neighboring gene uncharacterized LOC105376533 Neighboring gene olfactory receptor family 10 subfamily AB member 1 pseudogene Neighboring gene olfactory receptor family 5 subfamily P member 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ovochymase-2
Names
oviductin protease
NP_001354892.1
NP_937828.3
XP_016873148.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367963.1NP_001354892.1  ovochymase-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC104237
  2. NM_198185.7NP_937828.3  ovochymase-2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    ABBA01028682, AC104237
    Consensus CDS
    CCDS73251.1
    UniProtKB/TrEMBL
    A0A087X1V8
    Related
    ENSP00000484497.2, ENST00000533663.6
    Conserved Domains (3) summary
    smart00020
    Location:51294
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:431542
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:52297
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    7678623..7706894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017659.1XP_016873148.1  ovochymase-2 isoform X1

    Conserved Domains (3) summary
    smart00020
    Location:55298
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:435546
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:56301
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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