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Su(var)205 Suppressor of variegation 205 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34119, updated on 6-Sep-2022

Summary

Official Symbol
Su(var)205provided by FlyBase
Official Full Name
Suppressor of variegation 205provided by FlyBase
Primary source
FLYBASE:FBgn0003607
Locus tag
Dmel_CG8409
See related
AllianceGenome:FB:FBgn0003607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CBX5; CG8409; dHP-1a; dHP1; dHP1a; Dmel\CG8409; DmHP-1; DmHP1; E(var)29; E(var)29A; FBgn0003607; HP-1; hp1; Hp1; HP1; HP1-VS; hp1a; Hp1a; HP1a; HP1A; HP1alpha; Su(var); Su(var)2-05; Su(var)2-5; Su(Var)2-5; Su(var)2-501; su(var)205; Su(Var)205; SU(VAR)205; Su(var)29A; Su(var)[205]; Su-var(2)5; Sur(var)205; Suvar(2)5; Suvar2-5; Su[var]205; Su[Var]205
Summary
Enables chromatin binding activity and nucleic acid binding activity. Involved in several processes, including histone H4-K20 trimethylation; positive regulation of histone H3-K9 dimethylation; and regulation of gene expression. Located in chromosome and nucleus. Is active in pericentric heterochromatin. Is expressed in several structures, including embryonic/larval digestive system; embryonic/larval nervous system; extended germ band embryo; gonad; and presumptive embryonic/larval system. Orthologous to human CBX1 (chromobox 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Su(var)205 in Genome Data Viewer
Location:
28F2-28F3; 2-30 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8209626..8211122, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8209626..8211122, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44120 Neighboring gene long non-coding RNA:CR44121 Neighboring gene uncharacterized protein Neighboring gene Single stranded-binding protein c31A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone binding NAS
Non-traceable Author Statement
more info
PubMed 
enables mRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rDNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables satellite DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterochromatin formation HMP PubMed 
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H4-K20 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pericentric heterochromatin formation HMP PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of histone H3-K9 dimethylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of histone H3-K9 dimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
suppressor of variegation 205
Names
C1A9-nuclear-antigen
CG8409-PA
CG8409-PB
Su(var)2-5
Su(var)205-PA
Su(var)205-PB
heterochromatic protein
heterochromatic protein 1
heterochromatic protein 1a
heterochromatin factor 1
heterochromatin protein 1
heterochromatin protein 1A
heterochromatin protein-1
heterochromatin-binding protein
heterochromatin-protein-1
histone protein 1
suppressor of variegated 205

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8209626..8211122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057407.4NP_476755.1  suppressor of variegation 205, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476755.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05205, Q9VLR6
    Related
    FBpp0079251, FBtr0079635
    Conserved Domains (2) summary
    smart00300
    Location:141202
    ChSh; Chromo Shadow Domain
    cd00024
    Location:2472
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
  2. NM_164799.2NP_723361.1  suppressor of variegation 205, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05205, Q9VLR6
    Related
    FBpp0079252, FBtr0079636
    Conserved Domains (2) summary
    smart00300
    Location:141202
    ChSh; Chromo Shadow Domain
    cd00024
    Location:2472
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...