U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rbsn-5 Rabenosyn-5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34110, updated on 8-Apr-2026
Official Symbol
Rbsn-5provided by FlyBase
Official Full Name
Rabenosyn-5provided by FlyBase
Primary source
FLYBASE:FBgn0261064
Locus tag
Dmel_CG8506
See related
AllianceGenome:FB:FBgn0261064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8506; Dmel\CG8506; EEA1; MENE (2L)-C; MENE(2L)-C; rbsn; Rbsn; rbsn-5; Rbsn5
Summary
Enables small GTPase binding activity. Involved in several processes, including endosomal vesicle fusion; establishment of imaginal disc-derived wing hair orientation; and oocyte axis specification. Located in early endosome. Is expressed in adult head; embryonic/larval garland cell; organism; and spermatozoon. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Rbsn-5 in Genome Data Viewer
Location:
28E9-28E9; 2-30 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8159832..8161800)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8159832..8161800)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphatidic Acid Phospholipase A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Acyl-CoA binding protein 1 Neighboring gene piezo Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Oskar-induced endocytic activation and actin remodeling for anchorage of the Drosophila germ plasm. Tanaka T, et al. Bioarchitecture, 2011 May. PMID 21922042, Free PMC Article
  2. Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans. Qin QM, et al. PLoS Pathog, 2011 Jun. PMID 21698225, Free PMC Article
  3. Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization. Szatmári Z, et al. Mol Biol Cell, 2014 Feb. PMID 24356450, Free PMC Article
  4. Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis. Bechtel W, et al. J Am Soc Nephrol, 2013 Apr. PMID 23492732, Free PMC Article
  5. Endophilin B is required for the Drosophila oocyte to endocytose yolk downstream of Oskar. Tsai YC, et al. Development, 2014 Feb. PMID 24401369

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PI3K (III) differentially regulates localization of proteins at distinct membrane domains and Rbsn-5 mediates only a part of the PI3K (III)-dependent processes
    Title: Membrane protein location-dependent regulation by PI3K (III) and rabenosyn-5 in Drosophila wing cells.
  2. the Rbsn-Vps45 complex on early endosomes links Rab5 to the SNARE fusion machinery
    Title: Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of imaginal disc-derived wing hair orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton polarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane to endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Rabenosyn-5
Names
CG8506-PA
Rabenosyn5
Rbsn-5-PA
dRabenosyn
early endosomal antigen 1
rabenosyn

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8159832..8161800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135342.5 → NP_609186.1  Rabenosyn-5

    See identical proteins and their annotated locations for NP_609186.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLS5
    Related
    FBpp0079203
    Conserved Domains (2) summary
    cd15716
    Location:174 → 259
    FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
    pfam11464
    Location:449 → 487
    Rbsn; Rabenosyn Rab binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLS5 Q9VLS5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous