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POU2AF2 POU class 2 homeobox associating factor 2 [ Homo sapiens (human) ]

Gene ID: 341032, updated on 4-Nov-2022

Summary

Official Symbol
POU2AF2provided by HGNC
Official Full Name
POU class 2 homeobox associating factor 2provided by HGNC
Primary source
HGNC:HGNC:30527
See related
Ensembl:ENSG00000150750 AllianceGenome:HGNC:30527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCA-T1; C11orf53
Expression
Biased expression in testis (RPKM 1.3), colon (RPKM 0.7) and 13 other tissues See more
Orthologs
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Genomic context

See POU2AF2 in Genome Data Viewer
Location:
11q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111245725..111286401)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111255953..111296584)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111116450..111157126)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723966 Neighboring gene long intergenic non-protein coding RNA 2550 Neighboring gene ribosomal protein S17 pseudogene 15 Neighboring gene colorectal cancer associated 1 Neighboring gene POU class 2 homeobox associating factor 3 Neighboring gene uncharacterized LOC105369491

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC50104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
POU domain class 2-associating factor 2; uncharacterized protein C11orf53
Names
oct coactivator from tuft cells 1
protein POU2AF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198498.3NP_940900.2  POU domain class 2-associating factor 2

    Status: VALIDATED

    Source sequence(s)
    AP002448
    Consensus CDS
    CCDS31674.2
    UniProtKB/Swiss-Prot
    A0A1C7CYV6
    Related
    ENSP00000280325.6, ENST00000280325.7
    Conserved Domains (1) summary
    pfam17721
    Location:55288
    DUF5566; Family of unknown function (DUF5566)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    111245725..111286401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542804.3XP_011541106.2  uncharacterized protein C11orf53 isoform X1

    Related
    ENSP00000489630.1, ENST00000637637.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    111255953..111296584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)