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DCDC1 doublecortin domain containing 1 [ Homo sapiens (human) ]

Gene ID: 341019, updated on 11-Jun-2021

Summary

Official Symbol
DCDC1provided by HGNC
Official Full Name
doublecortin domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20625
See related
Ensembl:ENSG00000170959 MIM:608062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCDC5
Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]
Expression
Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.3) and 3 other tissues See more
Orthologs
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Genomic context

See DCDC1 in Genome Data Viewer
Location:
11p14.1-p13
Exon count:
52
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (30863603..31369810, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (30885150..31391286, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2859 Neighboring gene uncharacterized LOC101928338 Neighboring gene uncharacterized LOC107984419 Neighboring gene uncharacterized LOC105376611 Neighboring gene CYCS pseudogene 25 Neighboring gene DnaJ heat shock protein family (Hsp40) member C24 Neighboring gene inner mitochondrial membrane peptidase subunit 1 Neighboring gene HCNE8 enhancer downstream of PAX6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44078, FLJ46154, KIAA1493, MGC190499, MGC190811, DKFZp779D068

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Flemming body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
doublecortin domain-containing protein 1
Names
doublecortin domain-containing 5 protein
doublecortin domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367979.1NP_001354908.1  doublecortin domain-containing protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL133376, AL135932, AL137160, AL137804, AL162614
    Related
    ENSP00000472625.1, ENST00000597505.5
  2. NM_001387274.1NP_001374203.1  doublecortin domain-containing protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (6).
    Source sequence(s)
    AL133376, AL135932, AL137160, AL137804, AL162614
    Related
    ENSP00000507427.1, ENST00000684477.1
    Conserved Domains (7) summary
    cd00161
    Location:11631263
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cd17155
    Location:174245
    DCX_DCDC1; Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1)
    cd17156
    Location:9361013
    DCX1_DCDC5; Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17157
    Location:295380
    DCX2_DCDC5; Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17158
    Location:14121552
    DCX3_DCDC5; Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17159
    Location:16701742
    DCX4_DCDC5; Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5)
    cl28922
    Location:547580
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. NM_001387275.1NP_001374204.1  doublecortin domain-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL133349, AL135932
    Conserved Domains (3) summary
    cd00161
    Location:81181
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cd17158
    Location:330467
    DCX3_DCDC5; Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17159
    Location:585657
    DCX4_DCDC5; Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5)
  4. NM_020869.4NP_065920.2  doublecortin domain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL133349, AL135932
    Consensus CDS
    CCDS73270.1
    UniProtKB/TrEMBL
    B6ZDN3
    Related
    ENSP00000385936.3, ENST00000406071.6
    Conserved Domains (2) summary
    cd00161
    Location:270370
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl00155
    Location:514576
    UBQ; Ubiquitin-like proteins
  5. NM_181807.4NP_861523.2  doublecortin domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_861523.2

    Status: REVIEWED

    Source sequence(s)
    AA846321, AA954541, AY247970
    Consensus CDS
    CCDS7872.1
    UniProtKB/Swiss-Prot
    P59894
    Related
    ENSP00000389792.1, ENST00000452803.1
    Conserved Domains (1) summary
    cl00155
    Location:170252
    UBQ; Ubiquitin-like proteins

RNA

  1. NR_170625.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133376, AL135932, AL137160, AL137804, AL162614

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    30863603..31369810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448478.1XP_024304246.1  doublecortin domain-containing protein 1 isoform X6

    Conserved Domains (2) summary
    cd00161
    Location:10631163
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl25424
    Location:13071369
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  2. XM_024448476.1XP_024304244.1  doublecortin domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    cd00161
    Location:11181218
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl25424
    Location:13621424
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  3. XM_024448475.1XP_024304243.1  doublecortin domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    cd00161
    Location:11451245
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl25424
    Location:13891451
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  4. XM_024448477.1XP_024304245.1  doublecortin domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    cd00161
    Location:11631263
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl25424
    Location:9321014
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  5. XM_024448473.1XP_024304241.1  doublecortin domain-containing protein 1 isoform X1

    Conserved Domains (7) summary
    cd00161
    Location:11631263
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cd17155
    Location:174245
    DCX_DCDC1; Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1)
    cd17156
    Location:9361013
    DCX1_DCDC5; Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17157
    Location:295380
    DCX2_DCDC5; Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17158
    Location:14121552
    DCX3_DCDC5; Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17159
    Location:16701742
    DCX4_DCDC5; Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5)
    cl28922
    Location:547580
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  6. XM_024448471.1XP_024304239.1  doublecortin domain-containing protein 1 isoform X1

    Conserved Domains (7) summary
    cd00161
    Location:11631263
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cd17155
    Location:174245
    DCX_DCDC1; Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1)
    cd17156
    Location:9361013
    DCX1_DCDC5; Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17157
    Location:295380
    DCX2_DCDC5; Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17158
    Location:14121552
    DCX3_DCDC5; Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17159
    Location:16701742
    DCX4_DCDC5; Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5)
    cl28922
    Location:547580
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  7. XM_024448480.1XP_024304248.1  doublecortin domain-containing protein 1 isoform X8

    Conserved Domains (2) summary
    cd00161
    Location:878978
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl25424
    Location:11221184
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  8. XM_024448479.1XP_024304247.1  doublecortin domain-containing protein 1 isoform X7

    Conserved Domains (2) summary
    cd00161
    Location:9231023
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl25424
    Location:11671229
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  9. XM_024448481.1XP_024304249.1  doublecortin domain-containing protein 1 isoform X9

    Conserved Domains (2) summary
    cd00161
    Location:835935
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cl25424
    Location:10791141
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  10. XM_024448472.1XP_024304240.1  doublecortin domain-containing protein 1 isoform X1

    Conserved Domains (7) summary
    cd00161
    Location:11631263
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    cd17155
    Location:174245
    DCX_DCDC1; Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1)
    cd17156
    Location:9361013
    DCX1_DCDC5; Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17157
    Location:295380
    DCX2_DCDC5; Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17158
    Location:14121552
    DCX3_DCDC5; Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5)
    cd17159
    Location:16701742
    DCX4_DCDC5; Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5)
    cl28922
    Location:547580
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  11. XM_024448482.1XP_024304250.1  doublecortin domain-containing protein 1 isoform X10

    Conserved Domains (1) summary
    cl25424
    Location:9321014
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  12. XM_024448484.1XP_024304252.1  doublecortin domain-containing protein 1 isoform X12

    Conserved Domains (1) summary
    cl25424
    Location:170252
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  13. XM_024448483.1XP_024304251.1  doublecortin domain-containing protein 1 isoform X11

    Conserved Domains (1) summary
    cl25424
    Location:170252
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  14. XM_024448485.1XP_024304253.1  doublecortin domain-containing protein 1 isoform X13

    Conserved Domains (1) summary
    cl25424
    Location:170252
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  15. XM_024448486.1XP_024304254.1  doublecortin domain-containing protein 1 isoform X14

    Conserved Domains (1) summary
    cl25424
    Location:170252
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  16. XM_024448487.1XP_024304255.1  doublecortin domain-containing protein 1 isoform X15

    Conserved Domains (1) summary
    cl25424
    Location:170252
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  17. XM_024448488.1XP_024304256.1  doublecortin domain-containing protein 1 isoform X16

    Conserved Domains (1) summary
    cl25424
    Location:170252
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  18. XM_024448489.1XP_024304257.1  doublecortin domain-containing protein 1 isoform X17

    Conserved Domains (1) summary
    cl25424
    Location:170252
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

RNA

  1. XR_002957144.1 RNA Sequence

  2. XR_002957145.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001350255.1: Suppressed sequence

    Description
    NM_001350255.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
  2. NM_198462.2: Suppressed sequence

    Description
    NM_198462.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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