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CYP26C1 cytochrome P450 family 26 subfamily C member 1 [ Homo sapiens (human) ]

Gene ID: 340665, updated on 8-Jul-2021

Summary

Official Symbol
CYP26C1provided by HGNC
Official Full Name
cytochrome P450 family 26 subfamily C member 1provided by HGNC
Primary source
HGNC:HGNC:20577
See related
Ensembl:ENSG00000187553 MIM:608428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FFDD4
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CYP26C1 in Genome Data Viewer
Location:
10q23.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (93060798..93069540)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94820555..94829297)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1866 Neighboring gene exocyst complex component 6 Neighboring gene cytochrome P450 family 26 subfamily A member 1 Neighboring gene NIP7 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • FLJ45301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables retinoic acid 4-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables retinoic acid 4-hydroxylase activity TAS
Traceable Author Statement
more info
 
enables retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of retinoic acid receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neural crest cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in organelle fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in retinoic acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vitamin metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 26C1
Names
cytochrome P450, family 26, subfamily C, polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007958.1 RefSeqGene

    Range
    4535..13277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1290

mRNA and Protein(s)

  1. NM_183374.3NP_899230.2  cytochrome P450 26C1

    See identical proteins and their annotated locations for NP_899230.2

    Status: REVIEWED

    Source sequence(s)
    AL358613, AY356349
    Consensus CDS
    CCDS7425.1
    UniProtKB/Swiss-Prot
    Q6V0L0
    Related
    ENSP00000498424.1, ENST00000651965.1
    Conserved Domains (1) summary
    cl12078
    Location:40504
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    93060798..93069540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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