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LIPM lipase family member M [ Homo sapiens (human) ]

Gene ID: 340654, updated on 8-Jul-2021

Summary

Official Symbol
LIPMprovided by HGNC
Official Full Name
lipase family member Mprovided by HGNC
Primary source
HGNC:HGNC:23455
See related
Ensembl:ENSG00000173239 MIM:613923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIPL3; bA304I5.1
Expression
Biased expression in skin (RPKM 5.3), stomach (RPKM 0.7) and 2 other tissues See more
Orthologs
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Genomic context

See LIPM in Genome Data Viewer
Location:
10q23.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (88802730..88822022)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90562487..90580303)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase family member N Neighboring gene RCC1 and BTB domain containing protein 2 pseudogene 1 Neighboring gene ankyrin repeat domain 22 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene STAM binding protein like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipoprotein lipase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in cornification TAS
Traceable Author Statement
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lipase member M
Names
lipase M
lipase-like abhydrolase domain-containing protein 3
lipase-like, ab-hydrolase domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128215.1NP_001121687.1  lipase member M precursor

    See identical proteins and their annotated locations for NP_001121687.1

    Status: VALIDATED

    Source sequence(s)
    AL358532, BC157888, EF426484
    Consensus CDS
    CCDS44457.1
    UniProtKB/Swiss-Prot
    Q5VYY2
    Related
    ENSP00000383901.3, ENST00000404743.9
    Conserved Domains (3) summary
    pfam00561
    Location:92392
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:49111
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:93231
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    88802730..88822022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539748.3XP_011538050.1  lipase member M isoform X1

    See identical proteins and their annotated locations for XP_011538050.1

    Conserved Domains (3) summary
    pfam00561
    Location:92399
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:49111
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:93231
    Abhydrolase_5; Alpha/beta hydrolase family
  2. XM_011539753.2XP_011538055.1  lipase member M isoform X4

    Conserved Domains (2) summary
    pfam04083
    Location:49111
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:93231
    Abhydrolase_5; Alpha/beta hydrolase family
  3. XM_011539751.3XP_011538053.1  lipase member M isoform X2

    Conserved Domains (1) summary
    PLN02872
    Location:1283
    PLN02872; triacylglycerol lipase
  4. XM_011539752.3XP_011538054.1  lipase member M isoform X3

    Conserved Domains (1) summary
    PLN02872
    Location:1221
    PLN02872; triacylglycerol lipase
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