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LKRSDH Lysine ketoglutarate reductase/saccharopine dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34064, updated on 9-Dec-2024

Summary

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Official Symbol
LKRSDHprovided by FlyBase
Official Full Name
Lysine ketoglutarate reductase/saccharopine dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0286198
Locus tag
Dmel_CG7144
See related
AllianceGenome:FB:FBgn0286198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0149856.1; BEST:CK02318; CG7144; CK02318; dLKR; Dmel\CG7144; LKR; lys; SDH
Summary
Enables several functions, including nuclear receptor binding activity; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity; and transcription corepressor activity. Involved in lysine catabolic process; negative regulation of ecdysone receptor signaling pathway; and negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in adult head; adult heart; and salivary gland. Human ortholog(s) of this gene implicated in hyperlysinemia. Orthologous to human AASS (aminoadipate-semialdehyde synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See LKRSDH in Genome Data Viewer
Location:
28C4-28C4; 2-28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7791175..7795959, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7791175..7795959, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bromodomain containing 7/9 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44825 Neighboring gene Homocysteine-induced endoplasmic reticulum protein Neighboring gene r2d2 Neighboring gene Cell division cycle 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetics and biochemistry of red fat cells in Drosophila melanogaster. GRELL EH. Genetics, 1961 Aug. PMID 13708467, Free PMC Article
  2. Metabolomic Analysis Reveals That the Drosophila melanogaster Gene lysine Influences Diverse Aspects of Metabolism. St Clair SL, et al. Genetics, 2017 Dec. PMID 28986444, Free PMC Article
  3. LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes. Lv P, et al. Nat Commun, 2024 Apr 18. PMID 38637528, Free PMC Article
  4. dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes. Cakouros D, et al. J Cell Biol, 2008 Aug 11. PMID 18695041, Free PMC Article
  5. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. Emtenani S, et al. EMBO J, 2022 Jun 14. PMID 35319107, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our efforts revealed that lys encodes the Drosophila homolog of Lysine Ketoglutarate Reductase/Saccharopine Dehydrogenase, which is required for the enzymatic degradation of lysine. Furthermore, this approach also allowed us to simultaneously survey a large swathe of intermediate metabolism, thus demonstrating that Drosophila lysine catabolism is complex and capable of influencing seemingly unrelated metabolic pathways
    Title: Metabolomic Analysis Reveals That the Drosophila melanogaster Gene lysine Influences Diverse Aspects of Metabolism.
  2. A novel cofactor, Drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH), is involved in ecdysone-mediated transcription.
    Title: dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables saccharopine dehydrogenase (NAD+, L-lysine-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables saccharopine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in lysine biosynthetic process via aminoadipic acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ecdysone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lysine ketoglutarate reductase/saccharopine dehydrogenase
Names
CG7144-PA
CG7144-PB
LKRSDH-PA
LKRSDH-PB
drosophila lysine ketoglutarate reductase
drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH)
lysine
lysine ketoglutarate Reductase/Saccharopine dehydrogenase
lysine ketoglutarate reductase
saccharopine dehydogenase
NP_001285719.1
NP_609150.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7791175..7795959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298790.1 → NP_001285719.1  lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP53, Q9VLX0
    Conserved Domains (4) summary
    PLN02819
    Location:23 → 922
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
    cd12189
    Location:23 → 465
    LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
    pfam03435
    Location:486 → 602
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
    pfam16653
    Location:606 → 917
    Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain

  2. NM_135306.3 → NP_609150.2  lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609150.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP53, Q9VLX0
    Related
    FBpp0079118
    Conserved Domains (4) summary
    PLN02819
    Location:23 → 922
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
    cd12189
    Location:23 → 465
    LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
    pfam03435
    Location:486 → 602
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
    pfam16653
    Location:606 → 917
    Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLX0 Q9VLX0

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