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LKRSDH Lysine ketoglutarate reductase/saccharopine dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34064, updated on 8-Oct-2018

Summary

Official Symbol
LKRSDHprovided by FlyBase
Official Full Name
Lysine ketoglutarate reductase/saccharopine dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0025687
Locus tag
Dmel_CG7144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0149856.1; BEST:CK02318; CG7144; CK02318; dLKR; Dmel\CG7144; LKR; SDH

Genomic context

See LKRSDH in Genome Data Viewer
Location:
28C4-28C4; 2-28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7791175..7795959, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7791175..7795959, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Homocysteine-induced endoplasmic reticulum protein Neighboring gene r2d2 Neighboring gene cell division cycle 14

Genomic regions, transcripts, and products

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the LKRSDH gene: The LKRSDH gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
saccharopine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
lysine biosynthetic process via aminoadipic acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lysine ketoglutarate reductase/saccharopine dehydrogenase
Names
CG7144-PA
CG7144-PB
LKRSDH-PA
LKRSDH-PB
drosophila lysine ketoglutarate reductase
drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH)
lysine ketoglutarate reductase
saccharopine dehydogenase
NP_001285719.1
NP_609150.2

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7791175..7795959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298790.1NP_001285719.1  lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLX0
    Related
    FBpp0310050, FBtr0343404
    Conserved Domains (4) summary
    PLN02819
    Location:23922
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
    cd12189
    Location:23465
    LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
    pfam03435
    Location:486602
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
    pfam16653
    Location:606917
    Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain
  2. NM_135306.3NP_609150.2  lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609150.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLX0
    Related
    FBpp0079118, FBtr0079495
    Conserved Domains (4) summary
    PLN02819
    Location:23922
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
    cd12189
    Location:23465
    LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
    pfam03435
    Location:486602
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
    pfam16653
    Location:606917
    Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain
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