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DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 [ Homo sapiens (human) ]

Gene ID: 340578, updated on 12-Oct-2019

Summary

Official Symbol
DCAF12L2provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 12 like 2provided by HGNC
Primary source
HGNC:HGNC:32950
See related
Ensembl:ENSG00000198354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR40C
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 9. However, the CDS of this intronless gene remains intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]
Orthologs

Genomic context

See DCAF12L2 in Genome Data Viewer
Location:
Xq25
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (126163499..126166289, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (125297482..125300080, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene filamin binding LIM protein 1 pseudogene Neighboring gene uncharacterized LOC101928495 Neighboring gene uncharacterized LOC107985648 Neighboring gene MT-CO1 pseudogene 53

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 12-like protein 2
Names
WD repeat-containing protein 40C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021265.1 RefSeqGene

    Range
    4809..7599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001013628.3NP_001013650.1  DDB1- and CUL4-associated factor 12-like protein 2

    See identical proteins and their annotated locations for NP_001013650.1

    Status: REVIEWED

    Source sequence(s)
    AL445072, AY726580, BC136674
    Consensus CDS
    CCDS43991.1
    UniProtKB/Swiss-Prot
    Q5VW00
    Related
    ENSP00000353128.2, ENST00000360028.4
    Conserved Domains (2) summary
    COG2319
    Location:152417
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:100145
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    126163499..126166289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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