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ZC3H12B zinc finger CCCH-type containing 12B [ Homo sapiens (human) ]

Gene ID: 340554, updated on 5-Aug-2022

Summary

Official Symbol
ZC3H12Bprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 12Bprovided by HGNC
Primary source
HGNC:HGNC:17407
See related
Ensembl:ENSG00000102053 MIM:300889; AllianceGenome:HGNC:17407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCPIP2; CXorf32
Summary
The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in brain (RPKM 1.1), ovary (RPKM 0.5) and 22 other tissues See more
Orthologs
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Genomic context

See ZC3H12B in Genome Data Viewer
Location:
Xq11.2-q12
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (65034826..65507887)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (63460247..63934332)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64254706..64727767)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373239 Neighboring gene zinc finger C4H2-type containing Neighboring gene karyopherin subunit alpha 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 9838 Neighboring gene chaperonin containing TCP1 subunit 4 pseudogene 2 Neighboring gene mortality factor 4 like 1 pseudogene 5 Neighboring gene PRXL2C pseudogene 1 Neighboring gene TLE family member 1 pseudogene 1 Neighboring gene AP1M2 pseudogene 1 Neighboring gene LAS1 like ribosome biogenesis factor Neighboring gene FERM domain containing 8 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable ribonuclease ZC3H12B
Names
MCP-induced protein 2
zinc finger CCCH domain-containing protein 12B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021264.2 RefSeqGene

    Range
    5001..24153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010888.4NP_001010888.3  probable ribonuclease ZC3H12B

    See identical proteins and their annotated locations for NP_001010888.3

    Status: VALIDATED

    Source sequence(s)
    AL050306, AL355606, AL441964, AL591202, Z83841
    Consensus CDS
    CCDS48131.2
    UniProtKB/Swiss-Prot
    Q5H9C0, Q5HYM0
    Related
    ENSP00000340839.4, ENST00000338957.5
    Conserved Domains (1) summary
    pfam11977
    Location:189345
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    65034826..65507887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442075.1XP_047298031.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0
  2. XM_047442077.1XP_047298033.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0
  3. XM_047442076.1XP_047298032.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0
  4. XM_047442074.1XP_047298030.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0
  5. XM_047442079.1XP_047298035.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0
  6. XM_017029484.2XP_016884973.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0, Q5HYM0
    Conserved Domains (1) summary
    pfam11977
    Location:189345
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  7. XM_047442078.1XP_047298034.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0
  8. XM_047442080.1XP_047298036.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0
  9. XM_017029479.2XP_016884968.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0, Q5HYM0
    Conserved Domains (1) summary
    pfam11977
    Location:189345
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  10. XM_017029480.2XP_016884969.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0, Q5HYM0
    Conserved Domains (1) summary
    pfam11977
    Location:189345
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  11. XM_017029481.2XP_016884970.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0, Q5HYM0
    Conserved Domains (1) summary
    pfam11977
    Location:189345
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  12. XM_017029482.2XP_016884971.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0, Q5HYM0
    Conserved Domains (1) summary
    pfam11977
    Location:189345
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  13. XM_017029483.2XP_016884972.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/Swiss-Prot
    Q5H9C0, Q5HYM0
    Conserved Domains (1) summary
    pfam11977
    Location:189345
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  14. XM_011530939.3XP_011529241.1  probable ribonuclease ZC3H12B isoform X1

    See identical proteins and their annotated locations for XP_011529241.1

    UniProtKB/Swiss-Prot
    Q5H9C0, Q5HYM0
    Related
    ENSP00000512584.1, ENST00000696370.1
    Conserved Domains (1) summary
    pfam11977
    Location:189345
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    63460247..63934332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)