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BEX5 brain expressed X-linked 5 [ Homo sapiens (human) ]

Gene ID: 340542, updated on 5-Jan-2022

Summary

Official Symbol
BEX5provided by HGNC
Official Full Name
brain expressed X-linked 5provided by HGNC
Primary source
HGNC:HGNC:27990
See related
Ensembl:ENSG00000184515 MIM:300693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGFRAP1L1
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in brain (RPKM 24.8), thyroid (RPKM 6.2) and 10 other tissues See more
Orthologs
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Genomic context

See BEX5 in Genome Data Viewer
Location:
Xq22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (102153712..102155977, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101408684..101410949, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A like 2 Neighboring gene uncharacterized LOC105373299 Neighboring gene transcription elongation factor A like 6 Neighboring gene t-complex 11 family, X-linked 3, pseudogene Neighboring gene t-complex 11 family, X-linked 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104434, MGC126446

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein BEX5
Names
BEX family member 5
NGFRAP1-like 1
NGFRAP1-like protein 1
brain-expressed X-linked protein 5
nerve growth factor receptor-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012978.3NP_001012996.1  protein BEX5

    See identical proteins and their annotated locations for NP_001012996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY833564, BC106955
    Consensus CDS
    CCDS35350.1
    UniProtKB/Swiss-Prot
    Q5H9J7
    Related
    ENSP00000328030.3, ENST00000333643.4
    Conserved Domains (1) summary
    pfam04538
    Location:1107
    BEX; Brain expressed X-linked like family
  2. NM_001159560.2NP_001153032.1  protein BEX5

    See identical proteins and their annotated locations for NP_001153032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI985090, AY833564
    Consensus CDS
    CCDS35350.1
    UniProtKB/Swiss-Prot
    Q5H9J7
    Related
    ENSP00000446054.1, ENST00000543160.5
    Conserved Domains (1) summary
    pfam04538
    Location:1107
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    102153712..102155977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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