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NHSL2 NHS like 2 [ Homo sapiens (human) ]

Gene ID: 340527, updated on 27-Sep-2022

Summary

Official Symbol
NHSL2provided by HGNC
Official Full Name
NHS like 2provided by HGNC
Primary source
HGNC:HGNC:33737
See related
Ensembl:ENSG00000204131 AllianceGenome:HGNC:33737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in gall bladder (RPKM 1.5), fat (RPKM 1.1) and 24 other tissues See more
Orthologs
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Genomic context

See NHSL2 in Genome Data Viewer
Location:
Xq13.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71910845..72153286)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (70344419..70586866)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (71130695..71373136)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein CXorf49-like Neighboring gene chromosome X open reading frame 49 pseudogene Neighboring gene RNA, U6 small nuclear 1078, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1584 Neighboring gene ribosomal protein S26 pseudogene 11 Neighboring gene TPT1-like Neighboring gene retrotransposon Gag like 5 Neighboring gene RNA, 7SL, cytoplasmic 388, pseudogene Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44635, MGC169175, MGC169187

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NHS-like protein 2
Names
TPT1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029583.2 RefSeqGene

    Range
    5001..247442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001013627.3NP_001013649.2  NHS-like protein 2

    Status: VALIDATED

    Source sequence(s)
    AL929401, BX119917
    Consensus CDS
    CCDS87759.1
    UniProtKB/Swiss-Prot
    B2RN94
    UniProtKB/TrEMBL
    A0A0J9YY34
    Related
    ENSP00000488668.1, ENST00000633930.2
    Conserved Domains (2) summary
    PHA03247
    Location:721955
    PHA03247; large tegument protein UL36; Provisional
    pfam15273
    Location:500756
    NHS; NHS-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    71910845..72153286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442064.1XP_047298020.1  NHS-like protein 2 isoform X1

  2. XM_047442065.1XP_047298021.1  NHS-like protein 2 isoform X2

  3. XM_047442066.1XP_047298022.1  NHS-like protein 2 isoform X3

  4. XM_047442068.1XP_047298024.1  NHS-like protein 2 isoform X5

  5. XM_047442070.1XP_047298026.1  NHS-like protein 2 isoform X9

  6. XM_011530933.2XP_011529235.1  NHS-like protein 2 isoform X8

    Conserved Domains (1) summary
    pfam15273
    Location:479731
    NHS; NHS-like
  7. XM_011530932.2XP_011529234.1  NHS-like protein 2 isoform X7

    Conserved Domains (1) summary
    pfam15273
    Location:523775
    NHS; NHS-like
  8. XM_011530934.3XP_011529236.1  NHS-like protein 2 isoform X10

    Conserved Domains (1) summary
    pfam15273
    Location:313565
    NHS; NHS-like
  9. XM_047442067.1XP_047298023.1  NHS-like protein 2 isoform X4

    Related
    ENSP00000492082.1, ENST00000639939.1
  10. XM_047442069.1XP_047298025.1  NHS-like protein 2 isoform X6

  11. XM_047442071.1XP_047298027.1  NHS-like protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A0J9YY72
    Related
    ENSP00000488715.1, ENST00000631375.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    70344419..70586866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)