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ZDHHC21 zinc finger DHHC-type palmitoyltransferase 21 [ Homo sapiens (human) ]

Gene ID: 340481, updated on 23-Nov-2021

Summary

Official Symbol
ZDHHC21provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 21provided by HGNC
Primary source
HGNC:HGNC:20750
See related
Ensembl:ENSG00000175893 MIM:614605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNZ1; DHHC21; DHHC-21; HSPC097
Expression
Ubiquitous expression in brain (RPKM 3.1), skin (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZDHHC21 in Genome Data Viewer
Location:
9p22.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (14588797..14693432, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14611069..14693430, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nuclear factor I B Neighboring gene ribosomal protein L7a pseudogene 47 Neighboring gene tRNA-His (anticodon GTG) 1-6 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene uncharacterized LOC105375979 Neighboring gene cerberus 1, DAN family BMP antagonist Neighboring gene FRAS1 related extracellular matrix 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Novel associations for hypothyroidism include known autoimmune risk loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 9130404H11Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-cysteine S-palmitoyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hair follicle development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of establishment of endothelial barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of leukocyte adhesion to arterial endothelial cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
involved_in regulation of vascular associated smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sebaceous gland development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
palmitoyltransferase ZDHHC21
Names
DHHC domain-containing cysteine-rich protein 21
zinc finger DHHC-type containing 21
zinc finger, DHHC domain containing 21
NP_001341047.1
NP_001341048.1
NP_001341049.1
NP_001341050.1
NP_001341051.1
NP_001341052.1
NP_001341053.1
NP_001341054.1
NP_001341055.1
NP_001341056.1
NP_001341057.1
NP_001341058.1
NP_001341059.1
NP_848661.1
XP_016870171.1
XP_016870172.1
XP_016870180.1
XP_024303299.1
XP_024303300.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354118.2NP_001341047.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  2. NM_001354119.2NP_001341048.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  3. NM_001354120.2NP_001341049.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  4. NM_001354121.2NP_001341050.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  5. NM_001354122.2NP_001341051.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  6. NM_001354123.2NP_001341052.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  7. NM_001354124.2NP_001341053.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  8. NM_001354125.2NP_001341054.1  palmitoyltransferase ZDHHC21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:63188
    zf-DHHC; DHHC palmitoyltransferase
  9. NM_001354126.2NP_001341055.1  palmitoyltransferase ZDHHC21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:63188
    zf-DHHC; DHHC palmitoyltransferase
  10. NM_001354127.2NP_001341056.1  palmitoyltransferase ZDHHC21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:2120
    DHHC; DHHC palmitoyltransferase
  11. NM_001354128.2NP_001341057.1  palmitoyltransferase ZDHHC21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:2120
    DHHC; DHHC palmitoyltransferase
  12. NM_001354129.2NP_001341058.1  palmitoyltransferase ZDHHC21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:2120
    DHHC; DHHC palmitoyltransferase
  13. NM_001354130.2NP_001341059.1  palmitoyltransferase ZDHHC21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:2120
    DHHC; DHHC palmitoyltransferase
  14. NM_178566.6NP_848661.1  palmitoyltransferase ZDHHC21 isoform 1

    See identical proteins and their annotated locations for NP_848661.1

    Status: VALIDATED

    Source sequence(s)
    AK292960, AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    Q8IVQ6
    Related
    ENSP00000370303.3, ENST00000380916.9
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_148714.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732
  2. NR_148715.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732
  3. NR_148716.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732
  4. NR_148717.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732
  5. NR_148718.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    14588797..14693432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014691.1XP_016870180.1  palmitoyltransferase ZDHHC21 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:63188
    zf-DHHC; DHHC palmitoyltransferase
  2. XM_017014683.1XP_016870172.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  3. XM_024447531.1XP_024303299.1  palmitoyltransferase ZDHHC21 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  4. XM_017014682.1XP_016870171.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92217
    DHHC; DHHC palmitoyltransferase
  5. XM_024447532.1XP_024303300.1  palmitoyltransferase ZDHHC21 isoform X3

    Conserved Domains (1) summary
    cl19890
    Location:20216
    DHHC; DHHC palmitoyltransferase

RNA

  1. XR_001746285.1 RNA Sequence

  2. XR_001746286.1 RNA Sequence

  3. XR_001746284.1 RNA Sequence

  4. XR_002956779.1 RNA Sequence

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