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NRBP2 nuclear receptor binding protein 2 [ Homo sapiens (human) ]

Gene ID: 340371, updated on 11-Jun-2021

Summary

Official Symbol
NRBP2provided by HGNC
Official Full Name
nuclear receptor binding protein 2provided by HGNC
Primary source
HGNC:HGNC:19339
See related
Ensembl:ENSG00000185189 MIM:615563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRG16; pp9320
Expression
Ubiquitous expression in brain (RPKM 18.8), skin (RPKM 17.7) and 25 other tissues See more
Orthologs
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Genomic context

See NRBP2 in Genome Data Viewer
Location:
8q24.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (143829776..143840974, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144915753..144923145, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene scribble planar cell polarity protein Neighboring gene microRNA 937 Neighboring gene uncharacterized LOC107986985 Neighboring gene poly(U) binding splicing factor 60 Neighboring gene microRNA 6845 Neighboring gene epiplakin 1 Neighboring gene plectin Neighboring gene Sharpr-MPRA regulatory region 8265

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138699, DKFZp434P086

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear receptor-binding protein 2
Names
transformation-related protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178564.4NP_848659.2  nuclear receptor-binding protein 2

    See identical proteins and their annotated locations for NP_848659.2

    Status: VALIDATED

    Source sequence(s)
    AC234917, AI094905, AK293943, BC071605
    Consensus CDS
    CCDS34959.2
    UniProtKB/Swiss-Prot
    Q9NSY0
    Related
    ENSP00000414055.2, ENST00000442628.7
    Conserved Domains (1) summary
    cd14035
    Location:46307
    PK_MADML; Pseudokinase domain of MLF1-ADaptor Molecule-Like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    143829776..143840974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013382.1XP_016868871.1  nuclear receptor-binding protein 2 isoform X5

  2. XM_017013378.1XP_016868867.1  nuclear receptor-binding protein 2 isoform X1

  3. XM_017013379.1XP_016868868.1  nuclear receptor-binding protein 2 isoform X2

  4. XM_017013383.1XP_016868872.1  nuclear receptor-binding protein 2 isoform X6

  5. XM_017013380.1XP_016868869.1  nuclear receptor-binding protein 2 isoform X3

  6. XM_017013381.2XP_016868870.1  nuclear receptor-binding protein 2 isoform X4

RNA

  1. XR_001745529.1 RNA Sequence

  2. XR_001745528.1 RNA Sequence

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