Format

Send to:

Choose Destination

AGBL3 ATP/GTP binding protein like 3 [ Homo sapiens (human) ]

Gene ID: 340351, updated on 3-Apr-2018

Summary

Official Symbol
AGBL3provided by HGNC
Official Full Name
ATP/GTP binding protein like 3provided by HGNC
Primary source
HGNC:HGNC:27981
See related
Ensembl:ENSG00000146856 MIM:617346; Vega:OTTHUMG00000155406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCP3
Expression
Broad expression in testis (RPKM 2.0), endometrium (RPKM 0.4) and 16 other tissues See more
Orthologs

Genomic context

See AGBL3 in Genome Data Viewer
Location:
7q33
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (134986139..135135782)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134671259..134820530)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986850 Neighboring gene caldesmon 1 Neighboring gene ring finger protein 14 pseudogene Neighboring gene cell cycle regulator of NHEJ Neighboring gene transmembrane protein 140 Neighboring gene WD repeat domain 91 Neighboring gene microRNA 6509

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • FLJ12983, MGC32955

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein side chain deglutamylation IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytosolic carboxypeptidase 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345850.1NP_001332779.1  cytosolic carboxypeptidase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC083862, AC083870, AC090497
    Conserved Domains (1) summary
    cl11393
    Location:271
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  2. NM_001345851.1NP_001332780.1  cytosolic carboxypeptidase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC083862, AC083870, AC090497
  3. NM_001345852.1NP_001332781.1  cytosolic carboxypeptidase 3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform d. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AC083862, AC083870, AC090497
    Conserved Domains (1) summary
    cl11393
    Location:271
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  4. NM_001345853.1NP_001332782.1  cytosolic carboxypeptidase 3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform d. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AC083862, AC083870, AC090497
    Conserved Domains (1) summary
    cl11393
    Location:271
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  5. NM_178563.3NP_848658.3  cytosolic carboxypeptidase 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA707617, AC083862, AC090497, AK302827
    Consensus CDS
    CCDS47718.1
    UniProtKB/Swiss-Prot
    Q8NEM8
    Related
    ENSP00000388275.2, OTTHUMP00000225513, ENST00000436302.6, OTTHUMT00000376655
    Conserved Domains (1) summary
    cd06907
    Location:310570
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins

RNA

  1. NR_144293.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC083862, AC083870, AC090497

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    134986139..135135782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012137.2XP_016867626.1  cytosolic carboxypeptidase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEM8
    Conserved Domains (1) summary
    cd06907
    Location:310570
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  2. XM_017012140.2XP_016867629.1  cytosolic carboxypeptidase 3 isoform X4

  3. XM_017012142.2XP_016867631.1  cytosolic carboxypeptidase 3 isoform X6

  4. XM_017012143.2XP_016867632.1  cytosolic carboxypeptidase 3 isoform X7

    Related
    ENSP00000401220.2, OTTHUMP00000208040, ENST00000435976.6
  5. XM_017012138.2XP_016867627.1  cytosolic carboxypeptidase 3 isoform X2

  6. XM_017012139.2XP_016867628.1  cytosolic carboxypeptidase 3 isoform X3

  7. XM_024446749.1XP_024302517.1  cytosolic carboxypeptidase 3 isoform X9

    Conserved Domains (1) summary
    cl11393
    Location:271
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  8. XM_024446750.1XP_024302518.1  cytosolic carboxypeptidase 3 isoform X10

    Conserved Domains (1) summary
    cl11393
    Location:271
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  9. XM_011516122.3XP_011514424.1  cytosolic carboxypeptidase 3 isoform X8

    Conserved Domains (1) summary
    cl11393
    Location:310502
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  10. XM_017012136.2XP_016867625.1  cytosolic carboxypeptidase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEM8
    Conserved Domains (1) summary
    cd06907
    Location:310570
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  11. XM_017012141.2XP_016867630.1  cytosolic carboxypeptidase 3 isoform X5

RNA

  1. XR_001744699.2 RNA Sequence

  2. XR_001744696.2 RNA Sequence

  3. XR_001744698.2 RNA Sequence

  4. XR_001744697.2 RNA Sequence

Support Center