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TSPAN33 tetraspanin 33 [ Homo sapiens (human) ]

Gene ID: 340348, updated on 22-Aug-2020

Summary

Official Symbol
TSPAN33provided by HGNC
Official Full Name
tetraspanin 33provided by HGNC
Primary source
HGNC:HGNC:28743
See related
Ensembl:ENSG00000158457 MIM:610120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEN; PEN.; TSPAN-33
Expression
Broad expression in kidney (RPKM 45.5), lymph node (RPKM 15.7) and 20 other tissues See more
Orthologs

Genomic context

See TSPAN33 in Genome Data Viewer
Location:
7q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (129144707..129169699)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128784712..128809534)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CYCS pseudogene 20 Neighboring gene mitogen-activated protein kinase kinase 2 pseudogene Neighboring gene RNY1 pseudogene 11 Neighboring gene smoothened, frizzled class receptor Neighboring gene adenosylhomocysteinase like 2 Neighboring gene Sharpr-MPRA regulatory region 5606

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC50844

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
adherens junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
pore complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
tetraspanin-enriched microdomain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetraspanin-33
Names
penumbra
proerythroblast new membrane

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178562.5NP_848657.1  tetraspanin-33

    See identical proteins and their annotated locations for NP_848657.1

    Status: VALIDATED

    Source sequence(s)
    ABBA01057643, AC011005, AW089489, BC044244, HY012137
    Consensus CDS
    CCDS5810.1
    UniProtKB/Swiss-Prot
    Q86UF1
    Related
    ENSP00000483872.1, ENST00000486685.3
    Conserved Domains (1) summary
    cd03158
    Location:116236
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    129144707..129169699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715960.3XP_006716023.1  tetraspanin-33 isoform X1

    See identical proteins and their annotated locations for XP_006716023.1

    Conserved Domains (2) summary
    cd03158
    Location:115235
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:22263
    Tetraspannin; Tetraspanin family
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