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TSPAN33 tetraspanin 33 [ Homo sapiens (human) ]

Gene ID: 340348, updated on 22-Sep-2022

Summary

Official Symbol
TSPAN33provided by HGNC
Official Full Name
tetraspanin 33provided by HGNC
Primary source
HGNC:HGNC:28743
See related
Ensembl:ENSG00000158457 MIM:610120; AllianceGenome:HGNC:28743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEN; PEN.; TSPAN-33
Summary
Enables enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 45.5), lymph node (RPKM 15.7) and 20 other tissues See more
Orthologs
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Genomic context

See TSPAN33 in Genome Data Viewer
Location:
7q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (129144707..129169699)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (130457613..130482604)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128784712..128809540)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CYCS pseudogene 20 Neighboring gene mitogen-activated protein kinase kinase 2 pseudogene Neighboring gene RNY1 pseudogene 11 Neighboring gene smoothened, frizzled class receptor Neighboring gene Sharpr-MPRA regulatory region 13971

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC50844

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of pore complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in tetraspanin-enriched microdomain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetraspanin-33
Names
penumbra
proerythroblast new membrane

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178562.5NP_848657.1  tetraspanin-33

    See identical proteins and their annotated locations for NP_848657.1

    Status: VALIDATED

    Source sequence(s)
    ABBA01057643, AC011005, AW089489, BC044244, HY012137
    Consensus CDS
    CCDS5810.1
    UniProtKB/Swiss-Prot
    Q86UF1
    Related
    ENSP00000483872.1, ENST00000486685.3
    Conserved Domains (1) summary
    cd03158
    Location:116236
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    129144707..129169699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715960.4XP_006716023.1  tetraspanin-33 isoform X1

    See identical proteins and their annotated locations for XP_006716023.1

    Conserved Domains (1) summary
    cd03158
    Location:115235
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    130457613..130482604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)