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UNCX UNC homeobox [ Homo sapiens (human) ]

Gene ID: 340260, updated on 1-Jun-2020

Summary

Official Symbol
UNCXprovided by HGNC
Official Full Name
UNC homeoboxprovided by HGNC
Primary source
HGNC:HGNC:33194
See related
Ensembl:ENSG00000164853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNCX4.1
Summary
This gene encodes a homeobox transcription factor that is involved in somitogenesis and neurogenesis and is required for the maintenance and differentiation of specific elements of the axial skeleton. This gene also plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and deliver hormones that control peripheral functions. The expression of this gene is associated with an increased frequency of acute myeloid leukemia. [provided by RefSeq, Jul 2017]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See UNCX in Genome Data Viewer
Location:
7p22.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (1232872..1237326)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1272654..1276613)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ZFAND2A divergent transcript Neighboring gene VISTA enhancer hs293 Neighboring gene MS31A repeat instability region Neighboring gene MICAL like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
NHGRI GWA Catalog
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
NHGRI GWA Catalog

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cartilage condensation IEA
Inferred from Electronic Annotation
more info
 
common myeloid progenitor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
dorsal spinal cord development IEA
Inferred from Electronic Annotation
more info
 
olfactory bulb interneuron differentiation IEA
Inferred from Electronic Annotation
more info
 
pattern specification process IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
homeobox protein unc-4 homolog
Names
UNC homeobox protein
Unc4.1 homeobox
homeobox protein Uncx4.1
truncated UNCX homeobox protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080461.3NP_001073930.1  homeobox protein unc-4 homolog

    See identical proteins and their annotated locations for NP_001073930.1

    Status: REVIEWED

    Source sequence(s)
    AC073094
    Consensus CDS
    CCDS34583.1
    UniProtKB/Swiss-Prot
    A6NJT0
    Related
    ENSP00000314480.8, ENST00000316333.9
    Conserved Domains (1) summary
    pfam00046
    Location:108161
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    1232872..1237326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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