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ZNF680 zinc finger protein 680 [ Homo sapiens (human) ]

Gene ID: 340252, updated on 7-Dec-2018

Summary

Official Symbol
ZNF680provided by HGNC
Official Full Name
zinc finger protein 680provided by HGNC
Primary source
HGNC:HGNC:26897
See related
Ensembl:ENSG00000173041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 7.3), adrenal (RPKM 3.9) and 24 other tissues See more
Orthologs

Genomic context

See ZNF680 in Genome Data Viewer
Location:
7q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (64500253..64563135, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (63980255..64023505, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ZNF680 pseudogene 1 Neighboring gene vomeronasal 1 receptor 41 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 7 Neighboring gene BCL2 interacting protein 3 pseudogene 42 Neighboring gene PAGE family member 4 pseudogene Neighboring gene IgLON family member 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

General gene information

Markers

Homology

Clone Names

  • FLJ90430

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130022.1NP_001123494.1  zinc finger protein 680 isoform 2

    See identical proteins and their annotated locations for NP_001123494.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 3' coding region and 3' UTR, compared to variant 1, resulting in a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK131240, DA669757
    Consensus CDS
    CCDS47594.1
    UniProtKB/Swiss-Prot
    Q8NEM1
    Related
    ENSP00000393506.2, ENST00000447137.2
    Conserved Domains (2) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
    pfam01352
    Location:1352
    KRAB; KRAB box
  2. NM_178558.5NP_848653.2  zinc finger protein 680 isoform 1

    See identical proteins and their annotated locations for NP_848653.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC016769, BC030700, DA669757
    Consensus CDS
    CCDS34644.1
    UniProtKB/Swiss-Prot
    Q8NEM1
    Related
    ENSP00000309330.6, ENST00000309683.10
    Conserved Domains (6) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
    COG5048
    Location:152513
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:324344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:490512
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1352
    KRAB; KRAB box
    pfam13465
    Location:392416
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    64500253..64563135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012129.1XP_016867618.1  zinc finger protein 680 isoform X4

  2. XM_024446742.1XP_024302510.1  zinc finger protein 680 isoform X2

  3. XM_024446748.1XP_024302516.1  zinc finger protein 680 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_024446744.1XP_024302512.1  zinc finger protein 680 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_024446746.1XP_024302514.1  zinc finger protein 680 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_006715959.2XP_006716022.1  zinc finger protein 680 isoform X1

    See identical proteins and their annotated locations for XP_006716022.1

    Conserved Domains (5) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:111472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:449471
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:351375
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017012127.1XP_016867616.1  zinc finger protein 680 isoform X3

    UniProtKB/Swiss-Prot
    Q8NEM1
    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_017012128.1XP_016867617.1  zinc finger protein 680 isoform X3

    UniProtKB/Swiss-Prot
    Q8NEM1
    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_017012126.1XP_016867615.1  zinc finger protein 680 isoform X3

    UniProtKB/Swiss-Prot
    Q8NEM1
    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_024446743.1XP_024302511.1  zinc finger protein 680 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_024446747.1XP_024302515.1  zinc finger protein 680 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_024446745.1XP_024302513.1  zinc finger protein 680 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:44181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_001744687.1 RNA Sequence

  2. XR_002956429.1 RNA Sequence

  3. XR_002956428.1 RNA Sequence

  4. XR_428175.4 RNA Sequence

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