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MYLK4 myosin light chain kinase family member 4 [ Homo sapiens (human) ]

Gene ID: 340156, updated on 21-Dec-2022

Summary

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Official Symbol
MYLK4provided by HGNC
Official Full Name
myosin light chain kinase family member 4provided by HGNC
Primary source
HGNC:HGNC:27972
See related
Ensembl:ENSG00000145949 AllianceGenome:HGNC:27972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SgK085
Summary
Predicted to enable myosin light chain kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 1.8), thyroid (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

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See MYLK4 in Genome Data Viewer
Location:
6p25.2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (2663637..2770376, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (2529217..2636238, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (2663871..2770610, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene GMDS divergent transcript Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 28 Neighboring gene long intergenic non-protein coding RNA 1600 Neighboring gene long intergenic non-protein coding RNA 2521 Neighboring gene uncharacterized LOC124901240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2734004-2734694 Neighboring gene Sharpr-MPRA regulatory region 12436 Neighboring gene Sharpr-MPRA regulatory region 3200 Neighboring gene Sharpr-MPRA regulatory region 3960 Neighboring gene uncharacterized LOC124901241 Neighboring gene Sharpr-MPRA regulatory region 6984 Neighboring gene WRN helicase interacting protein 1 Neighboring gene serpin family B member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma. Yang M, et al. J Exp Clin Cancer Res, 2021 May 12. PMID 33980265, Free PMC Article
  2. Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations. Hong KW, et al. Genomics Inform, 2013 Sep. PMID 24124408, Free PMC Article
  3. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article
  5. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma.
    Title: MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  3. First identification, named SgK085 and classified as one of four myosin light chain kinases in a comprehensive analysis of protein kinases encoded by the human genome.
    Title: The protein kinase complement of the human genome.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin light chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin light chain kinase family member 4
Names
caMLCK like
sugen kinase 85
NP_001012418.2
NP_001334801.1
XP_005249135.2
XP_006715145.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052793.1 RefSeqGene

    Range
    24409..111694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012418.5 → NP_001012418.2  myosin light chain kinase family member 4 isoform 1

    See identical proteins and their annotated locations for NP_001012418.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK096893, AK122581, AL138876, BU675945, BX647582
    Consensus CDS
    CCDS34330.1
    UniProtKB/Swiss-Prot
    Q5TAW2, Q86YV6
    Related
    ENSP00000274643.7, ENST00000274643.9
    Conserved Domains (2) summary
    smart00220
    Location:110 → 361
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14193
    Location:101 → 361
    STKc_MLCK4; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4

  2. NM_001347872.2 → NP_001334801.1  myosin light chain kinase family member 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in a distinct 5' UTR and use of an alternate start codon. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK122581, AL138876, AL139092, BU675945, BX647582
    Consensus CDS
    CCDS93849.1
    UniProtKB/Swiss-Prot
    Q86YV6
    UniProtKB/TrEMBL
    A0A8V8TMV3
    Related
    ENSP00000514016.1, ENST00000698899.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    2663637..2770376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249078.5 → XP_005249135.2  myosin light chain kinase family member 4 isoform X1

  2. XM_006715082.4 → XP_006715145.1  myosin light chain kinase family member 4 isoform X2

    UniProtKB/TrEMBL
    A0A2R8Y4U5
    Related
    ENSP00000494309.1, ENST00000647417.1
    Conserved Domains (2) summary
    smart00220
    Location:104 → 355
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14193
    Location:95 → 355
    STKc_MLCK4; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4

RNA

  1. XR_926185.4 RNA Sequence

    Related
    ENST00000698900.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    2529217..2636238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86YV6.2 GenPept UniProtKB/Swiss-Prot:Q86YV6

Gene LinkOut

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