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ZC3H12D zinc finger CCCH-type containing 12D [ Homo sapiens (human) ]

Gene ID: 340152, updated on 17-Jun-2024

Summary

Official Symbol
ZC3H12Dprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 12Dprovided by HGNC
Primary source
HGNC:HGNC:21175
See related
Ensembl:ENSG00000178199 MIM:611106; AllianceGenome:HGNC:21175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFL; p34; MCPIP4; C6orf95; dJ281H8.1
Summary
Predicted to enable endoribonuclease activity and mRNA binding activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and negative regulation of cell growth. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 4.6), appendix (RPKM 3.5) and 11 other tissues See more
Orthologs
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Genomic context

See ZC3H12D in Genome Data Viewer
Location:
6q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149446795..149485014, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150646494..150684730, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149767931..149806150, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1 (MAP3K7) binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25253 Neighboring gene fatty acid binding protein 12 pseudogene 1 Neighboring gene MPRA-validated peak6211 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25254 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:149699707-149700906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149746425-149746924 Neighboring gene small ubiquitin like modifier 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149753111-149753397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149761776-149762690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149772303-149772854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149772855-149773406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25256 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149794343-149794528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149802875-149803730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149805477-149806341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149817836-149818336 Neighboring gene coiled-coil domain containing 59 pseudogene Neighboring gene peptidylprolyl isomerase like 4 Neighboring gene RNA, U7 small nuclear 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ00361, FLJ46041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in 3'-UTR-mediated mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
probable ribonuclease ZC3H12D
Names
Zinc finger CCCH domain-containing protein 12D
transformed follicular lymphoma
tumor suppressor TFL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207360.3NP_997243.2  probable ribonuclease ZC3H12D

    See identical proteins and their annotated locations for NP_997243.2

    Status: VALIDATED

    Source sequence(s)
    AL031133
    Consensus CDS
    CCDS47500.2
    UniProtKB/Swiss-Prot
    A1L178, A2A288, B2RXF4, B7WNU7, B9ZZP9, B9ZZQ0, Q6ZRW2
    Related
    ENSP00000386616.3, ENST00000409806.8
    Conserved Domains (2) summary
    PHA03215
    Location:286350
    PHA03215; nuclear protein UL24; Provisional
    pfam11977
    Location:88244
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    149446795..149485014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    150646494..150684730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)