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ARSI arylsulfatase family member I [ Homo sapiens (human) ]

Gene ID: 340075, updated on 24-Nov-2020

Summary

Official Symbol
ARSIprovided by HGNC
Official Full Name
arylsulfatase family member Iprovided by HGNC
Primary source
HGNC:HGNC:32521
See related
Ensembl:ENSG00000183876 MIM:610009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASI; SPG66
Summary
This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]
Expression
Broad expression in skin (RPKM 1.9), placenta (RPKM 1.8) and 20 other tissues See more
Orthologs

Genomic context

See ARSI in Genome Data Viewer
Location:
5q32
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (150296343..150302905, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149675909..149682525, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 7 Neighboring gene calcium/calmodulin dependent protein kinase II alpha Neighboring gene Sharpr-MPRA regulatory region 14436 Neighboring gene uncharacterized LOC105378225

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16069

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arylsulfatase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
arylsulfatase I
NP_001012301.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051250.1 RefSeqGene

    Range
    5058..11620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012301.4NP_001012301.1  arylsulfatase I precursor

    See identical proteins and their annotated locations for NP_001012301.1

    Status: REVIEWED

    Source sequence(s)
    AC011372, BC111002, BM670894, DA759270
    Consensus CDS
    CCDS34275.1
    UniProtKB/Swiss-Prot
    Q5FYB1
    Related
    ENSP00000333395.7, ENST00000328668.8
    Conserved Domains (1) summary
    cd16029
    Location:48478
    4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    150296343..150302905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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