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LRRC66 leucine rich repeat containing 66 [ Homo sapiens (human) ]

Gene ID: 339977, updated on 12-Oct-2019

Summary

Official Symbol
LRRC66provided by HGNC
Official Full Name
leucine rich repeat containing 66provided by HGNC
Primary source
HGNC:HGNC:34299
See related
Ensembl:ENSG00000188993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. [provided by RefSeq, Apr 2017]
Expression
Biased expression in duodenum (RPKM 4.6), small intestine (RPKM 4.1) and 4 other tissues See more
Orthologs

Genomic context

See LRRC66 in Genome Data Viewer
Location:
4q12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (51993652..52020363, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (52859806..52886477, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 4 Neighboring gene deoxyuridine triphosphatase pseudogene 7 Neighboring gene ribosomal protein L37a pseudogene 2 Neighboring gene sarcoglycan beta Neighboring gene long intergenic non-protein coding RNA 2480

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 66

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053164.1 RefSeqGene

    Range
    4949..31660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024611.3NP_001019782.1  leucine-rich repeat-containing protein 66

    See identical proteins and their annotated locations for NP_001019782.1

    Status: REVIEWED

    Source sequence(s)
    AC093858, BU620718, CA436716, CR749811
    Consensus CDS
    CCDS43229.1
    UniProtKB/Swiss-Prot
    Q68CR7
    Related
    ENSP00000341944.3, ENST00000343457.3
    Conserved Domains (3) summary
    cd00116
    Location:60255
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:88110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:171231
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    51993652..52020363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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