U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LRRC66 leucine rich repeat containing 66 [ Homo sapiens (human) ]

Gene ID: 339977, updated on 10-Dec-2024

Summary

Official Symbol
LRRC66provided by HGNC
Official Full Name
leucine rich repeat containing 66provided by HGNC
Primary source
HGNC:HGNC:34299
See related
Ensembl:ENSG00000188993 AllianceGenome:HGNC:34299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. [provided by RefSeq, Apr 2017]
Expression
Biased expression in duodenum (RPKM 4.6), small intestine (RPKM 4.1) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LRRC66 in Genome Data Viewer
Location:
4q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (51993652..52020363, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (55479597..55506301, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (52859818..52886529, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 4 Neighboring gene deoxyuridine triphosphatase pseudogene 7 Neighboring gene ribosomal protein L37a pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15421 Neighboring gene sarcoglycan beta Neighboring gene long intergenic non-protein coding RNA 2480

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
leucine-rich repeat-containing protein 66

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053164.1 RefSeqGene

    Range
    4949..31660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024611.3NP_001019782.1  leucine-rich repeat-containing protein 66 precursor

    See identical proteins and their annotated locations for NP_001019782.1

    Status: REVIEWED

    Source sequence(s)
    AC093858, BU620718, CA436716, CR749811
    Consensus CDS
    CCDS43229.1
    UniProtKB/Swiss-Prot
    Q68CR7
    Related
    ENSP00000508002.1, ENST00000682860.1
    Conserved Domains (3) summary
    cd00116
    Location:60255
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:88110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:171231
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    51993652..52020363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415645.1XP_047271601.1  leucine-rich repeat-containing protein 66 isoform X2

  2. XM_047415644.1XP_047271600.1  leucine-rich repeat-containing protein 66 isoform X1

  3. XM_047415646.1XP_047271602.1  leucine-rich repeat-containing protein 66 isoform X3

  4. XM_047415647.1XP_047271603.1  leucine-rich repeat-containing protein 66 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    55479597..55506301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349929.1XP_054205904.1  leucine-rich repeat-containing protein 66 isoform X2

  2. XM_054349928.1XP_054205903.1  leucine-rich repeat-containing protein 66 isoform X1

  3. XM_054349930.1XP_054205905.1  leucine-rich repeat-containing protein 66 isoform X3

  4. XM_054349931.1XP_054205906.1  leucine-rich repeat-containing protein 66 isoform X3