Format

Send to:

Choose Destination

TRIML1 tripartite motif family like 1 [ Homo sapiens (human) ]

Gene ID: 339976, updated on 23-Nov-2021

Summary

Official Symbol
TRIML1provided by HGNC
Official Full Name
tripartite motif family like 1provided by HGNC
Primary source
HGNC:HGNC:26698
See related
Ensembl:ENSG00000184108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF209
Summary
The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]
Expression
Restricted expression toward testis (RPKM 5.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TRIML1 in Genome Data Viewer
Location:
4q35.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (188137229..188150768)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (189060595..189068897)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif family like 2 Neighboring gene FAU pseudogene 3 Neighboring gene uncharacterized LOC107986337 Neighboring gene RNA, U6 small nuclear 173, pseudogene Neighboring gene long intergenic non-protein coding RNA 2434 Neighboring gene uncharacterized LOC105377607

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36180, MGC138638, MGC138639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase TRIML1
Names
RING finger protein 209
RING-type E3 ubiquitin transferase TRIML1
NP_848651.2
XP_006714270.1
XP_011530221.1
XP_024309796.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051631.1 RefSeqGene

    Range
    6253..14555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178556.5NP_848651.2  probable E3 ubiquitin-protein ligase TRIML1

    See identical proteins and their annotated locations for NP_848651.2

    Status: REVIEWED

    Source sequence(s)
    AK093499, BC015684, DB058735
    Consensus CDS
    CCDS3851.1
    UniProtKB/Swiss-Prot
    Q8N9V2
    Related
    ENSP00000327738.3, ENST00000332517.4
    Conserved Domains (3) summary
    pfam10249
    Location:130184
    NDUFB10; NADH-ubiquinone oxidoreductase subunit 10
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd13733
    Location:287462
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    188137229..188150768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454028.1XP_024309796.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

    Conserved Domains (1) summary
    cd13733
    Location:190365
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  2. XM_011531919.2XP_011530221.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

    Conserved Domains (1) summary
    cd13733
    Location:190365
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  3. XM_006714207.3XP_006714270.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X1

    Conserved Domains (3) summary
    pfam10249
    Location:130184
    NDUFB10; NADH-ubiquinone oxidoreductase subunit 10
    pfam15227
    Location:1656
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cl02614
    Location:287414
    SPRY; SPRY domain

RNA

  1. XR_001741216.1 RNA Sequence

Support Center