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TMPRSS11A transmembrane serine protease 11A [ Homo sapiens (human) ]

Gene ID: 339967, updated on 5-Jul-2025
Official Symbol
TMPRSS11Aprovided by HGNC
Official Full Name
transmembrane serine protease 11Aprovided by HGNC
Primary source
HGNC:HGNC:27954
See related
Ensembl:ENSG00000187054 MIM:611704; AllianceGenome:HGNC:27954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HESP; ECRG1; HATL1
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward esophagus (RPKM 55.7) See more
Orthologs
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See TMPRSS11A in Genome Data Viewer
Location:
4q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (67909395..67963493, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (71352520..71406589, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (68775113..68829211, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724780 Neighboring gene transmembrane serine protease 11D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:68792700-68793200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:68793201-68793701 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:68838367-68838888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:68838889-68839410 Neighboring gene transmembrane serine protease 11G, pseudogene Neighboring gene RNA, U6 small nuclear 95, pseudogene

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC133183

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transmembrane protease serine 11A
Names
airway trypsin-like protease 1
epidermal type-II transmembrane serine protease
esophageal cancer-susceptibility gene 1 protein
transmembrane protease, serine 11A

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114387.2NP_001107859.1  transmembrane protease serine 11A isoform 2

    See identical proteins and their annotated locations for NP_001107859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC096653, AC096727, AK292950, AY498712
    Consensus CDS
    CCDS47065.1
    UniProtKB/Swiss-Prot
    J3KNQ8, Q2NKI9, Q6JE90, Q6ZMR5, Q7RTY4, Q86TK8
    UniProtKB/TrEMBL
    A8KA85
    Related
    ENSP00000426911.2, ENST00000508048.6
    Conserved Domains (3) summary
    smart00020
    Location:186412
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:187415
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:49144
    SEA; SEA domain
  2. NM_182606.4NP_872412.3  transmembrane protease serine 11A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC096653, AC096727, AK131518, AK292950, AY498712
    Consensus CDS
    CCDS3519.1
    UniProtKB/TrEMBL
    A0A0A0MR82, A8KA85
    Related
    ENSP00000334611.7, ENST00000334830.11
    Conserved Domains (3) summary
    smart00020
    Location:189415
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:190418
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:49147
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    67909395..67963493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    71352520..71406589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)