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C3orf35 chromosome 3 open reading frame 35 [ Homo sapiens (human) ]

Gene ID: 339883, updated on 25-May-2017
Official Symbol
C3orf35provided by HGNC
Official Full Name
chromosome 3 open reading frame 35provided by HGNC
Primary source
HGNC:HGNC:24082
See related
Ensembl:ENSG00000198590 MIM:611429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APRG1
Annotation information
Note: This locus is considered non-coding by other groups due to a lack of experimental support for the protein, but NCBI annotates the protein because it meets minimal RefSeq quality criteria for representation. The coding status remains uncertain. [18 Nov 2014]
Orthologs
Location:
3p22.2
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (37379111..37435497)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37426477..37476988)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene golgin A4 Neighboring gene transcription elongation factor A1 pseudogene 2 Neighboring gene RNA, 5S ribosomal pseudogene 129 Neighboring gene integrin subunit alpha 9 Neighboring gene RNA, U7 small nuclear 73 pseudogene Neighboring gene ribosomal protein L21 pseudogene 135

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
AP20 region protein 1
Names
AP20 region protein1
APRG1 tumor suppressor candidate

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302831.1NP_001289760.1  AP20 region protein 1 isoform E

    See identical proteins and their annotated locations for NP_001289760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (H) contains alternate exon structure at both the 5' and 3' ends, resulting in alternate 5' and 3' UTRs and an alternate 3' coding region, compared to variant B. The encoded isoform (E) has a distinct C-terminus and is shorter than isoform B. Variants E, G, H and I all encode isoform E.
    Source sequence(s)
    AC136290, AJ493603, AJ493605, BC132691
    UniProtKB/Swiss-Prot
    Q8IVJ8
    UniProtKB/TrEMBL
    Q8IU91
    Related
    ENSP00000491645.1, ENST00000425564.2
  2. NM_001302832.1NP_001289761.1  AP20 region protein 1 isoform E

    See identical proteins and their annotated locations for NP_001289761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (I) contains alternate exon structure at both the 5' and 3' ends, resulting in alternate 5' and 3' UTRs and an alternate 3' coding region, compared to variant B. The encoded isoform (E) has a distinct C-terminus and is shorter than isoform B. Variants E, G, H and I all encode isoform E.
    Source sequence(s)
    AC136290, AJ493603, AJ493605, BC144377
    UniProtKB/Swiss-Prot
    Q8IVJ8
    UniProtKB/TrEMBL
    Q8IU91
  3. NM_178339.2NP_848029.2  AP20 region protein 1 isoform B

    See identical proteins and their annotated locations for NP_848029.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) encodes the longer isoform (B).
    Source sequence(s)
    AC092055, AJ493600, AJ493602, BC113895
    UniProtKB/Swiss-Prot
    Q8IVJ8
    UniProtKB/TrEMBL
    Q8IVJ6
    Related
    ENSP00000492757.1, ENST00000328376.9
  4. NM_178342.2NP_848032.1  AP20 region protein 1 isoform E

    See identical proteins and their annotated locations for NP_848032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (E) contains alternate 3' exon structure, resulting in an alternate 3' coding region and 3' UTR, compared to variant B. The encoded isoform (E) has a distinct C-terminus and is shorter than isoform B. Variants E, G, H and I all encode isoform E.
    Source sequence(s)
    AJ493603, BC113895, BC132691, DB349441
    UniProtKB/Swiss-Prot
    Q8IVJ8
    Related
    ENSP00000492433.1, ENST00000426078.5
  5. NM_178344.2NP_848034.2  AP20 region protein 1 isoform E

    See identical proteins and their annotated locations for NP_848034.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (G) contains alternate exon structure at both the 5' and 3' ends, resulting in alternate 5' and 3' UTRs and an alternate 3' coding region, compared to variant B. The encoded isoform (E) has a distinct C-terminus and is shorter than isoform B. Variants E, G, H and I all encode isoform E.
    Source sequence(s)
    AC136290, AJ493603, AJ493605, BC133024
    UniProtKB/Swiss-Prot
    Q8IVJ8
    UniProtKB/TrEMBL
    Q8IU91
    Related
    ENSP00000491390.1, ENST00000425932.5

RNA

  1. NR_126512.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) contains an additional internal exon and uses an alternate splice site in the 3' terminal exon, compared to variant B. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant B, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092055, AJ493599, AJ493601
    Related
    ENST00000332506.7
  2. NR_126513.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) lacks two internal exons and uses an alternate splice site in the 3' terminal exon, compared to variant B. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant B.
    Source sequence(s)
    AC092055, AJ493601
  3. NR_126514.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) lacks two internal exons, compared to variant B. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant B.
    Source sequence(s)
    AC092055, AJ493600, AJ493602
  4. NR_126515.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (F) lacks several 3' exons but contains an alternate 3' terminal exon, compared to variant B. This variant is represented as non-coding because it lacks the entire coding region found in variant B.
    Source sequence(s)
    AJ493601, AJ493604

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

    Range
    37379111..37435497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006291.1XP_016861780.1  AP20 region protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVJ8
  2. XM_017006294.1XP_016861783.1  AP20 region protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVJ8
  3. XM_017006292.1XP_016861781.1  AP20 region protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVJ8
  4. XM_017006296.1XP_016861785.1  AP20 region protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVJ8
  5. XM_017006293.1XP_016861782.1  AP20 region protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVJ8
  6. XM_017006295.1XP_016861784.1  AP20 region protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVJ8

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    37379371..37428598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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