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SPOPL speckle type BTB/POZ protein like [ Homo sapiens (human) ]

Gene ID: 339745, updated on 13-May-2022

Summary

Official Symbol
SPOPLprovided by HGNC
Official Full Name
speckle type BTB/POZ protein likeprovided by HGNC
Primary source
HGNC:HGNC:27934
See related
Ensembl:ENSG00000144228 AllianceGenome:HGNC:27934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTBD33
Summary
Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in appendix (RPKM 7.5), lymph node (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See SPOPL in Genome Data Viewer
Location:
2q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (138501770..138573547)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (138947462..139019229)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (139259340..139331117)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF14 pseudogene 1 Neighboring gene SPOPL divergent transcript Neighboring gene uncharacterized LOC124905958 Neighboring gene long intergenic non-protein coding RNA 2631

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ53775

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
speckle-type POZ protein-like
Names
HIB homolog 2
roadkill homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001664.3NP_001001664.1  speckle-type POZ protein-like

    See identical proteins and their annotated locations for NP_001001664.1

    Status: VALIDATED

    Source sequence(s)
    AC092620, AC114763
    Consensus CDS
    CCDS33298.1
    UniProtKB/Swiss-Prot
    Q6IQ16
    Related
    ENSP00000280098.4, ENST00000280098.9
    Conserved Domains (3) summary
    cd18343
    Location:179301
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:297392
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:28166
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    138501770..138573547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444116.1XP_047300072.1  speckle-type POZ protein-like isoform X1

  2. XM_047444115.1XP_047300071.1  speckle-type POZ protein-like isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    138947462..139019229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)