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SPOPL speckle type BTB/POZ protein like [ Homo sapiens (human) ]

Gene ID: 339745, updated on 11-Jun-2021

Summary

Official Symbol
SPOPLprovided by HGNC
Official Full Name
speckle type BTB/POZ protein likeprovided by HGNC
Primary source
HGNC:HGNC:27934
See related
Ensembl:ENSG00000144228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTBD33
Expression
Ubiquitous expression in appendix (RPKM 7.5), lymph node (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See SPOPL in Genome Data Viewer
Location:
2q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (138501770..138573547)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (139259340..139331117)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF14 pseudogene 1 Neighboring gene SPOPL divergent transcript Neighboring gene neurexophilin 2 Neighboring gene RN7SK pseudogene 286

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ53775

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
speckle-type POZ protein-like
Names
HIB homolog 2
roadkill homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001664.3NP_001001664.1  speckle-type POZ protein-like

    See identical proteins and their annotated locations for NP_001001664.1

    Status: VALIDATED

    Source sequence(s)
    AC092620, AC114763
    Consensus CDS
    CCDS33298.1
    UniProtKB/Swiss-Prot
    Q6IQ16
    Related
    ENSP00000280098.4, ENST00000280098.9
    Conserved Domains (3) summary
    cd18343
    Location:179301
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:297392
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:28166
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    138501770..138573547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263657.4XP_005263714.1  speckle-type POZ protein-like isoform X2

    See identical proteins and their annotated locations for XP_005263714.1

    Conserved Domains (3) summary
    cd18343
    Location:63185
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:181276
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:150
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
  2. XM_005263656.4XP_005263713.1  speckle-type POZ protein-like isoform X1

    See identical proteins and their annotated locations for XP_005263713.1

    Conserved Domains (2) summary
    cd18343
    Location:104226
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:222317
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
  3. XM_005263655.5XP_005263712.1  speckle-type POZ protein-like isoform X1

    See identical proteins and their annotated locations for XP_005263712.1

    Conserved Domains (2) summary
    cd18343
    Location:104226
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:222317
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
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