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SLC35E4 solute carrier family 35 member E4 [ Homo sapiens (human) ]

Gene ID: 339665, updated on 22-Sep-2022

Summary

Official Symbol
SLC35E4provided by HGNC
Official Full Name
solute carrier family 35 member E4provided by HGNC
Primary source
HGNC:HGNC:17058
See related
Ensembl:ENSG00000100036 AllianceGenome:HGNC:17058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable antiporter activity. Predicted to be involved in transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.9), colon (RPKM 1.3) and 22 other tissues See more
Orthologs
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Genomic context

See SLC35E4 in Genome Data Viewer
Location:
22q12.2
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30635781..30669019)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31099363..31132558)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31031768..31065006)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10016 Neighboring gene Sharpr-MPRA regulatory region 4664 Neighboring gene transcobalamin 2 Neighboring gene ribosomal protein L13a pseudogene 26 Neighboring gene dual specificity phosphatase 18 Neighboring gene oxysterol binding protein 2 Neighboring gene microRNA 3200 Neighboring gene Sharpr-MPRA regulatory region 14933

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129826

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 35 member E4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001479.4NP_001001479.1  solute carrier family 35 member E4 isoform 1

    See identical proteins and their annotated locations for NP_001001479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC005006, BC040191
    Consensus CDS
    CCDS13882.1
    UniProtKB/Swiss-Prot
    Q567P0, Q6ICL7
    Related
    ENSP00000339626.4, ENST00000343605.5
    Conserved Domains (3) summary
    pfam00892
    Location:188324
    EamA; EamA-like transporter family
    pfam03151
    Location:54325
    TPT; Triose-phosphate Transporter family
    cl23754
    Location:51178
    EamA; EamA-like transporter family
  2. NM_001318370.2NP_001305299.1  solute carrier family 35 member E4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC003072, AC005006, BC040191, BC093099
    Consensus CDS
    CCDS82708.1
    UniProtKB/Swiss-Prot
    Q6ICL7
    Related
    ENSP00000384377.1, ENST00000406566.1
    Conserved Domains (1) summary
    pfam00892
    Location:51178
    EamA; EamA-like transporter family
  3. NM_001318371.2NP_001305300.1  solute carrier family 35 member E4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC003072, AC005006, BC040191, BC063569
    UniProtKB/Swiss-Prot
    Q6ICL7
    Related
    ENSP00000413552.1, ENST00000451479.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    30635781..30669019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    31099363..31132558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)