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l(2)k09022 lethal (2) k09022 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33960, updated on 24-Nov-2022

Summary

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Official Symbol
l(2)k09022provided by FlyBase
Official Full Name
lethal (2) k09022provided by FlyBase
Primary source
FLYBASE:FBgn0086451
Locus tag
Dmel_CG10805
See related
AllianceGenome:FB:FBgn0086451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.160; CG10805; Dmel\CG10805
Summary
Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of transcription by RNA polymerase I. Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in pancreatic ductal carcinoma. Orthologous to human HEATR1 (HEAT repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See l(2)k09022 in Genome Data Viewer
Location:
27C1-27C1; 2-23 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6854142..6860849)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6854142..6860849)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene senseless-2 Neighboring gene Regulator of cyclin A1 Neighboring gene Na[+]/H[+] hydrogen antiporter 1 Neighboring gene long non-coding RNA:CR44915

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Venken KJ, et al. Science, 2006 Dec 15. PMID 17138868
  2. Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth. Furrer M, et al. J Biol Chem, 2010 Dec 17. PMID 20937797, Free PMC Article
  3. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
  4. Functional genomics identifies TOR-regulated genes that control growth and division. Guertin DA, et al. Curr Biol, 2006 May 23. PMID 16713952
  5. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of t-UTP complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
lethal (2) k09022
Names
CG10805-PA
l(2)k09022-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6854142..6860849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135235.3 → NP_609079.2  lethal (2) k09022 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609079.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T9E7, Q9VM75
    Related
    FBpp0078971, FBtr0079343
    Conserved Domains (2) summary
    smart01036
    Location:1818 → 1966
    BP28CT; BP28CT (NUC211) domain
    pfam12397
    Location:236 → 350
    U3snoRNP10; U3 small nucleolar RNA-associated protein 10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM75.2 Q9VM75

Gene LinkOut

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