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ZFP69 ZFP69 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 339559, updated on 23-Nov-2021

Summary

Official Symbol
ZFP69provided by HGNC
Official Full Name
ZFP69 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:24708
See related
Ensembl:ENSG00000187815 MIM:617939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP69A; ZNF642; ZSCAN54A; ZKSCAN23A
Expression
Ubiquitous expression in testis (RPKM 2.2), spleen (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZFP69 in Genome Data Viewer
Location:
1p34.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (40477220..40496343)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40942962..40962015)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11139 Neighboring gene ZFP69 zinc finger protein B Neighboring gene EXO5 divergent transcript Neighboring gene exonuclease 5 Neighboring gene Sharpr-MPRA regulatory region 98 Neighboring gene zinc finger protein 684

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • FLJ16030

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger protein 69 homolog
Names
ZFP69 zinc finger protein A
zinc finger protein 642
zinc finger protein ZFP69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320178.2NP_001307107.1  zinc finger protein 69 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK122618, AL603839, BC041873, BC144174, BM677727
    UniProtKB/Swiss-Prot
    Q49AA0
    Conserved Domains (4) summary
    smart00349
    Location:76137
    KRAB; krueppel associated box
    COG5048
    Location:233516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:366
    SCAN; SCAN oligomerization domain
  2. NM_001320179.2NP_001307108.1  zinc finger protein 69 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1 by a single amino acid. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AK122618, AL603839, BC041873, BM677727
    Consensus CDS
    CCDS30686.1
    UniProtKB/Swiss-Prot
    Q49AA0
    Related
    ENSP00000361791.1, ENST00000372706.6
    Conserved Domains (4) summary
    smart00349
    Location:76136
    KRAB; krueppel associated box
    COG5048
    Location:232515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:366
    SCAN; SCAN oligomerization domain
  3. NM_198494.3NP_940896.2  zinc finger protein 69 homolog isoform 2

    See identical proteins and their annotated locations for NP_940896.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1 by a single amino acid. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AL603839, BM677727, CV374692, CX871163, DA687888
    Consensus CDS
    CCDS30686.1
    UniProtKB/Swiss-Prot
    Q49AA0
    Related
    ENSP00000361790.3, ENST00000372705.3
    Conserved Domains (4) summary
    smart00349
    Location:76136
    KRAB; krueppel associated box
    COG5048
    Location:232515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:366
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    40477220..40496343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270809.4XP_005270866.1  zinc finger protein 69 homolog isoform X1

    See identical proteins and their annotated locations for XP_005270866.1

    Conserved Domains (4) summary
    smart00349
    Location:76137
    KRAB; krueppel associated box
    COG5048
    Location:233516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:366
    SCAN; SCAN oligomerization domain
  2. XM_006710606.3XP_006710669.1  zinc finger protein 69 homolog isoform X2

    See identical proteins and their annotated locations for XP_006710669.1

    UniProtKB/Swiss-Prot
    Q49AA0
    Conserved Domains (4) summary
    smart00349
    Location:76136
    KRAB; krueppel associated box
    COG5048
    Location:232515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:366
    SCAN; SCAN oligomerization domain
  3. XM_006710605.3XP_006710668.1  zinc finger protein 69 homolog isoform X1

    See identical proteins and their annotated locations for XP_006710668.1

    Conserved Domains (4) summary
    smart00349
    Location:76137
    KRAB; krueppel associated box
    COG5048
    Location:233516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:366
    SCAN; SCAN oligomerization domain
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