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ZFP69 ZFP69 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 339559, updated on 2-Oct-2018

Summary

Official Symbol
ZFP69provided by HGNC
Official Full Name
ZFP69 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:24708
See related
Ensembl:ENSG00000187815 MIM:617939; Vega:OTTHUMG00000007303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP69A; ZNF642; ZSCAN54A; ZKSCAN23A
Expression
Ubiquitous expression in testis (RPKM 2.2), spleen (RPKM 1.5) and 25 other tissues See more
Orthologs

Genomic context

See ZFP69 in Genome Data Viewer
Location:
1p34.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (40477220..40496343)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40943043..40962015)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small ArfGAP2 Neighboring gene ZFP69 zinc finger protein B Neighboring gene uncharacterized LOC105378672 Neighboring gene exonuclease 5 Neighboring gene zinc finger protein 684

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

General gene information

Markers

Homology

Clone Names

  • FLJ16030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger protein 69 homolog; zinc finger protein ZFP69
Names
ZFP69 zinc finger protein A
zinc finger protein 642

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320178.1NP_001307107.1  zinc finger protein 69 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK122618, BC041873, BC144174, BM677727
    UniProtKB/Swiss-Prot
    Q49AA0
    Conserved Domains (7) summary
    smart00349
    Location:76137
    KRAB; krueppel associated box
    COG5048
    Location:233516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:272294
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:76115
    KRAB; KRAB box
    pfam13465
    Location:286311
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:441
    SCAN; SCAN oligomerization domain
  2. NM_001320179.1NP_001307108.1  zinc finger protein 69 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1 by a single amino acid. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AK122618, BC041873, BM677727
    Consensus CDS
    CCDS30686.1
    UniProtKB/Swiss-Prot
    Q49AA0
    Related
    ENSP00000361791.1, OTTHUMP00000008381, ENST00000372706.5, OTTHUMT00000019082
    Conserved Domains (7) summary
    smart00349
    Location:76136
    KRAB; krueppel associated box
    COG5048
    Location:232515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:271293
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:76115
    KRAB; KRAB box
    pfam13465
    Location:285310
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:441
    SCAN; SCAN oligomerization domain
  3. NM_198494.2NP_940896.2  zinc finger protein 69 homolog isoform 2

    See identical proteins and their annotated locations for NP_940896.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1 by a single amino acid. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AL603839, BM677727, CV374692, CX871163, DA687888
    Consensus CDS
    CCDS30686.1
    UniProtKB/Swiss-Prot
    Q49AA0
    Related
    ENSP00000361790.3, OTTHUMP00000008382, ENST00000372705.3, OTTHUMT00000019083
    Conserved Domains (7) summary
    smart00349
    Location:76136
    KRAB; krueppel associated box
    COG5048
    Location:232515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:271293
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:76115
    KRAB; KRAB box
    pfam13465
    Location:285310
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:441
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    40477220..40496343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270809.4XP_005270866.1  zinc finger protein ZFP69 isoform X1

    See identical proteins and their annotated locations for XP_005270866.1

    Conserved Domains (7) summary
    smart00349
    Location:76137
    KRAB; krueppel associated box
    COG5048
    Location:233516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:272294
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:76115
    KRAB; KRAB box
    pfam13465
    Location:286311
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:441
    SCAN; SCAN oligomerization domain
  2. XM_006710606.3XP_006710669.1  zinc finger protein ZFP69 isoform X2

    See identical proteins and their annotated locations for XP_006710669.1

    UniProtKB/Swiss-Prot
    Q49AA0
    Conserved Domains (7) summary
    smart00349
    Location:76136
    KRAB; krueppel associated box
    COG5048
    Location:232515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:271293
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:76115
    KRAB; KRAB box
    pfam13465
    Location:285310
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:441
    SCAN; SCAN oligomerization domain
  3. XM_006710605.3XP_006710668.1  zinc finger protein ZFP69 isoform X1

    See identical proteins and their annotated locations for XP_006710668.1

    Conserved Domains (7) summary
    smart00349
    Location:76137
    KRAB; krueppel associated box
    COG5048
    Location:233516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:272294
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:76115
    KRAB; KRAB box
    pfam13465
    Location:286311
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:441
    SCAN; SCAN oligomerization domain
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