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ZFP69 ZFP69 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 339559, updated on 19-May-2026
Official Symbol
ZFP69provided by HGNC
Official Full Name
ZFP69 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:24708
See related
Ensembl:ENSG00000187815 MIM:617939; AllianceGenome:HGNC:24708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP69A; ZNF642; ZSCAN54A; ZKSCAN23A
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of lipid metabolic process and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 2.2), spleen (RPKM 1.5) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ZFP69 in Genome Data Viewer
Location:
1p34.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40477290..40496343)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40346903..40365936)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40942962..40962015)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ZFP69B divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 728 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:40916242-40917441 Neighboring gene ZFP69 zinc finger protein B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 729 Neighboring gene EXO5 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 847 Neighboring gene exonuclease 5 Neighboring gene uncharacterized LOC124904149 Neighboring gene Sharpr-MPRA regulatory region 98

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. Scherneck S, et al. PLoS Genet, 2009 Jul. PMID 19578398, Free PMC Article
  2. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article
  4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  5. Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids. Broderick K, et al. Nat Commun, 2025 Jul 1. PMID 40593736, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Zfp69 is the most likely candidate for the diabetogenic effect of Nidd/SJL locus.
    Title: Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
zinc finger protein 69 homolog
Names
ZFP69 zinc finger protein A
zinc finger protein 642
zinc finger protein ZFP69

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320178.2 → NP_001307107.1  zinc finger protein 69 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK122618, AL603839, BC041873, BC144174, BM677727
    UniProtKB/Swiss-Prot
    Q49AA0
    Related
    ENSP00000523197.1, ENST00000853138.1
    Conserved Domains (4) summary
    smart00349
    Location:76 → 137
    KRAB; krueppel associated box
    COG5048
    Location:233 → 516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:3 → 66
    SCAN; SCAN oligomerization domain

  2. NM_001320179.2 → NP_001307108.1  zinc finger protein 69 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1 by a single amino acid. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AK122618, AL603839, BC041873, BM677727
    Consensus CDS
    CCDS30686.1
    UniProtKB/Swiss-Prot
    Q49AA0, Q5SWM5, Q6ZWK8
    Related
    ENSP00000361791.1, ENST00000372706.6
    Conserved Domains (4) summary
    smart00349
    Location:76 → 136
    KRAB; krueppel associated box
    COG5048
    Location:232 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:3 → 66
    SCAN; SCAN oligomerization domain

  3. NM_198494.3 → NP_940896.2  zinc finger protein 69 homolog isoform 2

    See identical proteins and their annotated locations for NP_940896.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1 by a single amino acid. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AL603839, BM677727, CV374692, CX871163, DA687888
    Consensus CDS
    CCDS30686.1
    UniProtKB/Swiss-Prot
    Q49AA0, Q5SWM5, Q6ZWK8
    Related
    ENSP00000361790.3, ENST00000372705.3
    Conserved Domains (4) summary
    smart00349
    Location:76 → 136
    KRAB; krueppel associated box
    COG5048
    Location:232 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:3 → 66
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40477290..40496343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270809.5 → XP_005270866.1  zinc finger protein 69 homolog isoform X1

    See identical proteins and their annotated locations for XP_005270866.1

    Related
    ENSP00000523196.1, ENST00000853137.1
    Conserved Domains (4) summary
    smart00349
    Location:76 → 137
    KRAB; krueppel associated box
    COG5048
    Location:233 → 516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:3 → 66
    SCAN; SCAN oligomerization domain

  2. XM_006710606.4 → XP_006710669.1  zinc finger protein 69 homolog isoform X2

    See identical proteins and their annotated locations for XP_006710669.1

    UniProtKB/Swiss-Prot
    Q49AA0, Q5SWM5, Q6ZWK8
    Related
    ENSP00000523193.1, ENST00000853134.1
    Conserved Domains (4) summary
    smart00349
    Location:76 → 136
    KRAB; krueppel associated box
    COG5048
    Location:232 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:3 → 66
    SCAN; SCAN oligomerization domain

  3. XM_006710605.4 → XP_006710668.1  zinc finger protein 69 homolog isoform X1

    See identical proteins and their annotated locations for XP_006710668.1

    Related
    ENSP00000523194.1, ENST00000853135.1
    Conserved Domains (4) summary
    smart00349
    Location:76 → 137
    KRAB; krueppel associated box
    COG5048
    Location:233 → 516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:3 → 66
    SCAN; SCAN oligomerization domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    40346903..40365936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336303.1 → XP_054192278.1  zinc finger protein 69 homolog isoform X1

  2. XM_054336305.1 → XP_054192280.1  zinc finger protein 69 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q49AA0, Q5SWM5, Q6ZWK8

  3. XM_054336304.1 → XP_054192279.1  zinc finger protein 69 homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q49AA0.2 GenPept UniProtKB/Swiss-Prot:Q49AA0

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