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PRSS38 serine protease 38 [ Homo sapiens (human) ]

Gene ID: 339501, updated on 23-Nov-2023

Summary

Official Symbol
PRSS38provided by HGNC
Official Full Name
serine protease 38provided by HGNC
Primary source
HGNC:HGNC:29625
See related
Ensembl:ENSG00000185888 AllianceGenome:HGNC:29625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPN2
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 1.8) See more
Orthologs
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Genomic context

See PRSS38 in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (227815675..227846470)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227004591..227035389)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228003376..228034171)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227928395-227928940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227928941-227929485 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:227929473-227929676 Neighboring gene synaptosome associated protein 47 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:227937705-227938206 Neighboring gene jumonji domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:227949169-227949919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:227952921-227953670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227953671-227954420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227961766-227962583 Neighboring gene MPRA-validated peak747 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227965808-227966590 Neighboring gene LOC105373289 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227980229-227980892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227981557-227982220 Neighboring gene MPRA-validated peak748 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228073527-228074122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228074123-228074719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228083643-228084489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228087252-228087752 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228088986-228089986 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:228101825-228101974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228102681-228103478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228103479-228104275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228107156-228108019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228108020-228108882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228114017-228114769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228117534-228118094 Neighboring gene negCOR silencer S7 Neighboring gene Wnt family member 9A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228129831-228130733 Neighboring gene uncharacterized LOC124904533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1903 Neighboring gene microRNA 5008

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC163272

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease 38
Names
marapsin 2
protease, serine 38
serine protease MPN2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374657.2NP_001361586.1  serine protease 38 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL356323, AL731702
    Conserved Domains (1) summary
    cd00190
    Location:60197
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_183062.3NP_898885.1  serine protease 38 isoform 1 precursor

    See identical proteins and their annotated locations for NP_898885.1

    Status: VALIDATED

    Source sequence(s)
    AL356323, AL731702
    Consensus CDS
    CCDS1563.1
    UniProtKB/Swiss-Prot
    A1L453, Q7RTY6
    Related
    ENSP00000355719.3, ENST00000366757.4
    Conserved Domains (1) summary
    cd00190
    Location:60291
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    227815675..227846470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544175.3XP_011542477.1  serine protease 38 isoform X1

    Conserved Domains (2) summary
    smart00020
    Location:59192
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:60192
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    227004591..227035389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336279.1XP_054192254.1  serine protease 38 isoform X1