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PRSS38 serine protease 38 [ Homo sapiens (human) ]

Gene ID: 339501, updated on 5-Aug-2018

Summary

Official Symbol
PRSS38provided by HGNC
Official Full Name
serine protease 38provided by HGNC
Primary source
HGNC:HGNC:29625
See related
Ensembl:ENSG00000185888 Vega:OTTHUMG00000037701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPN2
Expression
Restricted expression toward testis (RPKM 1.8) See more
Orthologs

Genomic context

See PRSS38 in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (227815708..227846470)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228003418..228034171)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 47 Neighboring gene jumonji domain containing 4 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene Wnt family member 9A Neighboring gene microRNA 5008 Neighboring gene uncharacterized LOC107985355

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163272

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease 38
Names
marapsin 2
protease, serine 38
serine protease MPN2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183062.2NP_898885.1  serine protease 38 precursor

    See identical proteins and their annotated locations for NP_898885.1

    Status: VALIDATED

    Source sequence(s)
    AA398170, BN000131
    Consensus CDS
    CCDS1563.1
    UniProtKB/Swiss-Prot
    A1L453
    Related
    ENSP00000355719.3, OTTHUMP00000035840, ENST00000366757.3, OTTHUMT00000091981
    Conserved Domains (2) summary
    smart00020
    Location:59288
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:60291
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    227815708..227846470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544176.3XP_011542478.1  serine protease 38 isoform X2

    Conserved Domains (2) summary
    smart00020
    Location:59192
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:60197
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_011544175.2XP_011542477.1  serine protease 38 isoform X1

    Conserved Domains (2) summary
    smart00020
    Location:59192
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:60192
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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