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RXFP4 relaxin family peptide/INSL5 receptor 4 [ Homo sapiens (human) ]

Gene ID: 339403, updated on 13-Feb-2019


Official Symbol
RXFP4provided by HGNC
Official Full Name
relaxin family peptide/INSL5 receptor 4provided by HGNC
Primary source
See related
Ensembl:ENSG00000173080 MIM:609043
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

Genomic context

See RXFP4 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (155941689..155942834)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155911480..155912625)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene small Cajal body-specific RNA 4 Neighboring gene uncharacterized LOC107985207 Neighboring gene Rho/Rac guanine nucleotide exchange factor 2 Neighboring gene microRNA 6738 Neighboring gene uncharacterized LOC107985209

Genomic regions, transcripts, and products


GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Relaxin receptors, organism-specific biosystem (from REACTOME)
    Relaxin receptors, organism-specific biosystemRelaxins are part of a family of peptide hormones that diverged from insulin in early vertebrate evolution to form the insulin-like peptides and relaxins, now often referred to as the relaxin peptide...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC126556, MGC126558

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
galanin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
positive regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
relaxin-3 receptor 2
G protein-coupled receptor 100
G-protein coupled receptor GPCR142
RLN3 receptor 2
insulin-like peptide INSL5 receptor
relaxin family peptide receptor 4
relaxin/insulin like family peptide receptor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181885.2NP_871001.1  relaxin-3 receptor 2

    See identical proteins and their annotated locations for NP_871001.1

    Status: VALIDATED

    Source sequence(s)
    AY288415, DN693323
    Consensus CDS
    ENSP00000357301.3, ENST00000368318.4
    Conserved Domains (1) summary
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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