Format

Send to:

Choose Destination

ADAMTSL5 ADAMTS like 5 [ Homo sapiens (human) ]

Gene ID: 339366, updated on 21-Dec-2019

Summary

Official Symbol
ADAMTSL5provided by HGNC
Official Full Name
ADAMTS like 5provided by HGNC
Primary source
HGNC:HGNC:27912
See related
Ensembl:ENSG00000185761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THSD6
Expression
Broad expression in endometrium (RPKM 3.3), heart (RPKM 2.8) and 21 other tissues See more
Orthologs

Genomic context

See ADAMTSL5 in Genome Data Viewer
Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1505018..1513038, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1505017..1513188, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene receptor accessory protein 6 Neighboring gene uncharacterized LOC107985337 Neighboring gene polo like kinase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
microfibril IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microfibril IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADAMTS-like protein 5
Names
ADAMTSL-5
thrombospondin type-1 domain-containing protein 6
thrombospondin, type I, domain containing 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367197.1NP_001354126.1  ADAMTS-like protein 5 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC027307, AW167554, BX951496
    Conserved Domains (4) summary
    smart00209
    Location:4897
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:375476
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:206311
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:106174
    ADAM_CR; ADAM cysteine-rich
  2. NM_213604.3NP_998769.2  ADAMTS-like protein 5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK131571, BC040620, BC119796, DR979736
    Consensus CDS
    CCDS12071.1
    UniProtKB/Swiss-Prot
    Q6ZMM2
    UniProtKB/TrEMBL
    Q0VD77, X6R4H8
    Related
    ENSP00000327608.3, ENST00000330475.9
    Conserved Domains (4) summary
    smart00209
    Location:3887
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:365466
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:196301
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:96164
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1505018..1513038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527961.1XP_011526263.1  ADAMTS-like protein 5 isoform X1

    Conserved Domains (4) summary
    smart00209
    Location:4897
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:379480
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:206315
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:106174
    ADAM_CR; ADAM cysteine-rich
  2. XM_017026744.1XP_016882233.1  ADAMTS-like protein 5 isoform X3

  3. XM_011527963.1XP_011526265.1  ADAMTS-like protein 5 isoform X5

    See identical proteins and their annotated locations for XP_011526265.1

    UniProtKB/TrEMBL
    A4QPG6
    Conserved Domains (2) summary
    cd03523
    Location:134235
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:370
    ADAM_spacer1; ADAM-TS Spacer 1
  4. XM_017026745.1XP_016882234.1  ADAMTS-like protein 5 isoform X4

    UniProtKB/TrEMBL
    X6R4H8
    Conserved Domains (4) summary
    smart00209
    Location:3887
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:365466
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:196301
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:96164
    ADAM_CR; ADAM cysteine-rich
Support Center