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ZNF181 zinc finger protein 181 [ Homo sapiens (human) ]

Gene ID: 339318, updated on 13-Mar-2020

Summary

Official Symbol
ZNF181provided by HGNC
Official Full Name
zinc finger protein 181provided by HGNC
Primary source
HGNC:HGNC:12971
See related
Ensembl:ENSG00000197841 MIM:606741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHZ181
Summary
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]
Expression
Ubiquitous expression in ovary (RPKM 3.5), thyroid (RPKM 2.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF181 in Genome Data Viewer
Location:
19q13.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (34734194..34746483)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35225103..35233774)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 2B member 1, pseudogene Neighboring gene secretoglobin family 1B member 1, pseudogene Neighboring gene zinc finger protein 599 Neighboring gene zinc finger protein 134 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC44316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029997.4NP_001025168.2  zinc finger protein 181 isoform 1

    See identical proteins and their annotated locations for NP_001025168.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC020910, AI800428, AK297316, BC104759, DC299701, DC304794
    Consensus CDS
    CCDS32990.2
    UniProtKB/Swiss-Prot
    Q2M3W8
    UniProtKB/TrEMBL
    B4DM69
    Related
    ENSP00000420727.1, ENST00000492450.3
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:211539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463483
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001145665.2NP_001139137.1  zinc finger protein 181 isoform 2

    See identical proteins and their annotated locations for NP_001139137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1, and encodes a protein (isoform 2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AC020910, AI800428, AK297316, BC143442, DC299701, DC304794
    Consensus CDS
    CCDS46043.1
    UniProtKB/Swiss-Prot
    Q2M3W8
    UniProtKB/TrEMBL
    B4DM69
    Related
    ENSP00000419435.1, ENST00000459757.6
    Conserved Domains (6) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:210538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462482
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:516538
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:502526
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    34734194..34746483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723183.3XP_006723246.1  zinc finger protein 181 isoform X1

    See identical proteins and their annotated locations for XP_006723246.1

    UniProtKB/Swiss-Prot
    Q2M3W8
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:211539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463483
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_005258851.3XP_005258908.1  zinc finger protein 181 isoform X3

    See identical proteins and their annotated locations for XP_005258908.1

    Conserved Domains (6) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:207535
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:513535
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:499523
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006723184.3XP_006723247.1  zinc finger protein 181 isoform X4

    Conserved Domains (6) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:206534
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458478
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:512534
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:498522
    zf-H2C2_2; Zinc-finger double domain
  4. XM_005258849.2XP_005258906.1  zinc finger protein 181 isoform X1

    See identical proteins and their annotated locations for XP_005258906.1

    UniProtKB/Swiss-Prot
    Q2M3W8
    Related
    ENSP00000376065.3, ENST00000392232.7
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:211539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:463483
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_005258850.2XP_005258907.1  zinc finger protein 181 isoform X2

    See identical proteins and their annotated locations for XP_005258907.1

    UniProtKB/Swiss-Prot
    Q2M3W8
    Conserved Domains (6) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:210538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462482
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:516538
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:502526
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017026739.2XP_016882228.1  zinc finger protein 181 isoform X2

    UniProtKB/Swiss-Prot
    Q2M3W8
    Conserved Domains (6) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:210538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462482
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:516538
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:502526
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017026740.1XP_016882229.1  zinc finger protein 181 isoform X5

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